哮喘联盟

   摘要
   肥胖是成人发生哮喘的危险因素，也是代谢综合症的一个主要组成成分。本研究旨在探索代谢综合征及其组成成分与成人哮喘累计发生率的相关性。我们开展了一个前瞻性队列研究，参与者为1995-2008Nord-Trøndelag健康研究中基线检查无哮喘的人群（n=23 191）。根据几个国际组织临时联合声明的定义，将基线代谢综合征进行分类。随访期间自行报告哮喘发生，平均随访11年。代谢综合征是哮喘发生的危险因素（校正OR 1.57, 95% CI 1.31 - 1.87）。在使用更严格哮喘定义的敏感性分析中，此相关性始终存在（校正OR 1.42, 95% CI 1.13 - 1.79）。在代谢综合征组成成分中，经其它代谢成分相互校正后还有两种代谢成分与哮喘发生有关：高腰围（校正OR 1.62, 95% CI 1.36 to 1.94）和血糖升高或糖尿病（校正OR 1.43, 95% CI 1.01 to 2.04）。代谢综合征和其中两个组成成分（高腰围，血糖升高或糖尿病）与成人哮喘发生风险增加相关。
 

（苏楠 审校）
Eur Respir J. 2013 Jul 11. [Epub ahead of print]

 

Metabolic syndrome and incidence of asthma in adults: the HUNT study.
 

Brumpton BM, Camargo CA Jr, Romundstad PR, Langhammer A, Chen Y, Mai XM.
 

Abstract
Obesity is a risk factor for incident asthma in adults, and obesity is a major component of metabolic syndrome. This study aimed to explore the associations of metabolic syndrome and its components with the cumulative incidence of asthma in adults.We conducted a prospective cohort study of participants who were asthma-free at baseline (n=23 191) in the Nord-Trøndelag Health Study from 1995 to 2008. Baseline metabolic syndrome was categorized using the definition of the Joint Interim Statement from several international organizations. Incident asthma was self-reported at follow-up, which averaged 11 years.Metabolic syndrome was a risk factor for incident asthma (adjusted OR 1.57, 95% CI 1.31 to 1.87). This association was consistent in sensitivity analyses using a stricter asthma definition (adjusted OR 1.42, 95% CI 1.13 to 1.79). Among the components of metabolic syndrome, two remained associated with incident asthma after mutual adjustment for the other metabolic components; high waist circumference (adjusted OR 1.62, 95% CI 1.36 to 1.94), and elevated glucose or diabetes (adjusted OR 1.43, 95% CI 1.01 to 2.04).Metabolic syndrome and two of its components (high waist circumference, and elevated glucose or diabetes) were associated with an increased risk of incident asthma in adults.
 

Eur Respir J. 2013 Jul 11. [Epub ahead of print]