哮喘联盟

   摘要
   背景：虽然有许多新的药理学机制药物以及新的药物组合的选择,但哮喘控制不理想的比例仍然很高。因此,临床早期诊断、哮喘控制不良的行为因素干预以及日常门诊干预等改善哮喘发作的管理措施被强烈推荐。本研究旨在评估土耳其哮喘患者的特征和吸入装置与哮喘控制之间的关系。
   方法：这项前瞻性观察研究共纳入572例持续性哮喘患者(平均年龄(标准偏差)：42.7岁(12.1)，女性占76%)。一次基线访问(0月,第一次访问)和三次后续访问(报名后1、3和6个月)收集了人口统计学特征、哮喘史和吸入装置使用的数据。
   结果：不论社会人口因素、哮喘持续时间、体重指数或吸烟状况如何，第1次访问有61.5%的患者哮喘控制，第4次访问增加至87.3%(P < 0.001)。哮喘相关疾病的存在，显著负面影响哮喘控制 (P = 0.004)。随访中使用各种不同固定剂量联合治疗吸入器的患者的哮喘未控制比例显著减少 (每个之间P < 0.001)。Logistic回归分析表明哮喘相关疾病的存在(OR 0.602，95% CI，0.419；0.863，P = 0.006)和主动吸烟(OR, 0.522；95% CI；0.330；0.825，P = 0.005)是哮喘控制的重要预测因子。
   结论：我们的研究表明，成年持续性哮喘门诊患者虽然接受了治疗，但第1次随访的哮喘控制率仅为61.5%。不过，在最后随访的6个月后哮喘控制率增加至87.3%，而且不受社会人口因素和临床特征的影响。哮喘控制不良与哮喘相关疾病有关，而固定剂量的联合治疗在实现哮喘控制中的作用非常明显。
 

（刘国梁 审校）
J Asthma Allergy. 2013 Jul 1;6:93-101. doi: 10.2147/JAA.S45269. Print 2013.
 

Factors influencing asthma control: results of a real-life prospective observational asthma inhaler treatment (ASIT) study.
 

Yıldız F; ASIT Study Group.
 

Abstract
BACKGROUND: Despite the availability of new pharmacological options and novel combinations of existing drug therapies, the rate of suboptimal asthma control is still high. Therefore, early identification of the clinical and behavioral factors responsible for poor asthma control, and interventions during routine outpatient visits to improve asthma trigger management, are strongly recommended. This study was designed to evaluate the profiles of asthmatic patients and their inhaler treatment devices in relation to asthma control in Turkey.
METHODS: A total of 572 patients with persistent asthma (mean [standard deviation] age: 42.7 [12.1] years; 76% female) were included in this prospective observational study. A baseline visit (0 month, visit 1) and three follow-up visits (1, 3 and 6 months after enrolment) were conducted to collect data on demographics, past medical and asthma history, and inhaler device use.
RESULTS: Asthma control was identified in 61.5% of patients at visit 1 and increased to 87.3% at visit 4 (P < 0.001), regardless of sociodemographics, asthma duration, body mass index or smoking status. The presence of asthma-related comorbidity had a significantly negative effect on asthma control (P = 0.004). A significant decrease was determined, in the rate of uncontrolled asthma, upon follow-up among patients who were using a variety of fixed dose combination inhalers (P < 0.001 for each). Logistic regression analysis was used to show that the presence of asthma-related comorbidity (odds ratio [OR], 0.602; 95% confidence interval [CI], 0.419; 0.863, P = 0.006) and active smoking (OR, 0.522; 95% CI, 0.330; 0.825, P = 0.005) were significant predictors of asthma control.
CONCLUSION: Our findings indicate that, despite ongoing treatment, asthma control rate was 61.5% at visit 1 in adult outpatients with persistent asthma. However, by the final follow-up 6 months later, this had increased to 87.3%, independent of sociodemographic and clinical characteristics. Poor asthma control was associated with asthma-related comorbid diseases, while the efficacy of fixed dose combinations was evident in the achievement of asthma control.
 

J Asthma Allergy. 2013 Jul 1;6:93-101. doi: 10.2147/JAA.S45269. Print 2013.