哮喘联盟

   摘要
   基础理论：（行为）补偿是减少香烟中可利用的尼古丁和焦油含量的一个潜在结果。很少有发表的数据将（行为）补偿和戒烟联系起来。
   目标：我们旨在研究由限制香烟（焦油和尼古丁）含量得到的（行为）补偿是否与戒烟困难相关。
   方法：将采集的174例有意戒烟的吸烟者的问卷调查和血液样本作为一个更大的戒烟研究的一部分。参与者被指示使用一个过滤器来消除香烟中50％的焦油和尼古丁，但仍可以正常吸烟。参与者在使用过滤器采集3天随访数据后返回。
   结果：使用过滤器后，每天的尼古丁水平和香烟量减少。基线尼古丁水平和使用过滤器前/后尼古丁水平的变化，而不是每日香烟量或每日香烟量的改变与戒烟30天相关。
   结论：对烟草烟雾中的尼古丁含量下降而出现的生物或行为后果表现敏感的吸烟者的戒烟难度更大。这些研究结果表明，我们需要与行为补偿联系起来的个体化的戒烟治疗。

（林江涛 审校）
Psychopharmacology (Berl). 2013 Jun 10. [Epub ahead of print]

 

Compensation predicts smoking cessation failure.

Niaura RS, Pearson JL, Abrams DB.
 

Abstract
RATIONALE: Compensation is a potential result of decreasing the available nicotine and tar dose in cigarettes. There is little published data linking compensation with cessation.
OBJECTIVES: We sought to examine whether compensation in response to restricted cigarette yield is associated with difficulty quitting smoking.
METHODS: Questionnaires and blood samples were collected from 174 smokers interested in quitting smoking as part of a larger smoking cessation study. Participants were instructed to use a filter designed to remove 50 % of tar and nicotine from the cigarette but otherwise smoke normally. Participants returned after 3 days of using the filter for follow-up data collection.
RESULTS: Nicotine levels and cigarettes per day decreased after use of the filter. Baseline nicotine and change in nicotine pre/post filter use, but not cigarettes per day or change in cigarettes per day were associated with smoking abstinence at 30 days.
CONCLUSIONS: Smokers who demonstrate sensitivity to the biological or behavioral consequences of decreased nicotine content in tobacco smoke have greater difficulty quitting. These findings suggest the need for personalized cessation treatment linked to behavioral compensation.
 

Psychopharmacology (Berl). 2013 Jun 10. [Epub ahead of print]