抗病毒药物在哮喘急性加重中的潜在效用
2013/07/17
摘要
哮喘是最常见的慢性呼吸道疾病，其患病率与日俱增。幼年的呼吸道病毒感染可以增加日后发生哮喘的危险，病毒感染仍然是促进哮喘急性加重的最强单因子。开发有效的抗病毒治疗仍是干预治疗的关键目标。本文讨论了呼吸道病毒感染在哮喘急性加重中的作用，重点突出了现在和潜在的抗病毒治疗药物以及它们的作用机制。
（苏楠 审校）
CurrOpinPharmacol.2013May8.pii:S1471-4892(13)00059-3.doi:10.1016/j.coph.2013.04.010. [Epub ahead of print]
Anti-viral agents: potential utility in exacerbations of asthma.
Dhariwal J, Edwards MR, Johnston SL.
Abstract
Asthma is the most common chronic respiratory disease and its prevalence is on the increase. Respiratory viral infections in early life have been suggested to increase the risk of development of asthma in later life and virus infection remains the single greatest precipitant of asthma exacerbations. The development of effective anti-viral treatments remains a key target for therapeutic intervention. Here we discuss the role of respiratory viral infection in asthma exacerbation and highlight current and potential anti-viral agents and their mechanisms of action.
CurrOpinPharmacol.2013May8.pii:S1471-4892(13)00059-3.doi:10.1016/j.coph.2013.04.010. [Epub ahead of print]
