哮喘联盟

   摘要
   哮喘是一种与诸多环境因素高度相关的疾病，例如过敏原和污染物都可以诱发哮喘。其中，气道炎症是哮喘最关键的病理症状之一。为了确定造成呼吸道炎症的原因，我们全面检测了活性氧（ROS）的独特作用。证据表明，多种加重化合物如过敏源的吸入可以促进活性氧的增加。因此，活性氧在很多呼吸道疾病(如哮喘)导致的呼吸道炎症中起到了细胞信号转导的作用。虽然哮喘不能治愈，目前的治疗是有效缓解炎症症状。基于哮喘发病机制和活性氧形成机制的研究，已经证实了几个新的抗炎治疗方法，阐明了哮喘治疗的基本理念。本文将概述哮喘的发病机制以及与活性氧、氧化应激和肺部炎症的相关性。

 

（苏楠 审校）
Mol Immunol. 2013 May 9;56(1-2):57-63. doi: 10.1016/j.molimm.2013.04.002. [Epub ahead of print]

 

Molecular mechanisms of reactive oxygen species-related pulmonary inflammation and asthma.
 

Zuo L, Otenbaker NP, Rose BA, Salisbury KS.

Abstract
Asthma is a highly relevant disorder that can be induced by many environmental factors such as allergens and pollutants. One of the most critical pathological symptoms of asthma is airway inflammation. In order to identify a cause of respiratory inflammation, we thoroughly examine the unique role of reactive oxygen species (ROS). Evidence supports that the inhalation of aggravating compounds such as allergens can promote the increased generation of ROS. Accordingly, ROS have a proven role in the cellular signaling cascades of many respiratory diseases that cause respiratory inflammation, including asthma. Although there is no known cure for asthma, current treatments effectively lessen the inflammation symptom. Based on the investigations of asthma pathogenesis and the mechanism of ROS formation, we have identified several novel anti-inflammatory therapeutic treatments, shedding light on a fundamental understanding for the cure of this disorder. In this review, we will outline the pathogenesis of asthma and its relationship to ROS, oxidative stress, and pulmonary inflammation.

Mol Immunol. 2013 May 9;56(1-2):57-63. doi: 10.1016/j.molimm.2013.04.002. [Epub ahead of print]