哮喘联盟

   摘要
   背景：最新文献指出，葡萄球菌肠毒素特异性IgE可能是哮喘的危险因素
   目的：本研究旨在分析葡萄球菌肠毒素的致敏作用与哮喘的关系
   方法：对2013年2月前发表在同行评议期刊上的病例对照或基于人群的研究进行系统性回顾和meta分析。数据主要提取了研究设计、研究对象、定义和葡萄球菌肠毒素致敏的发生率
   结果：最初共纳入683项研究，其中7项研究最终符合入选标准(5项病例对照和2项基于人群的研究)。在纳入的所有研究中，尽管临床和方法学上具有特异性，但哮喘患者的致敏发生率高于对照组。而且，荟萃分析发现，哮喘患者致敏汇总优势比为2.95(95%可信区间2.28-3.82)
   结论：葡萄球菌肠毒素的致敏作用与哮喘显著相关。相关机制需要进一步阐释。
 

（苏楠 审校）
Asia Pac Allergy. 2013 Apr;3(2):120-6. doi: 10.5415/apallergy.2013.3.2.120. Epub 2013 Apr 26.
 

Staphylococcal enterotoxin specific IgE and asthma: a systematic review and meta-analysis.

Song WJ, Jo EJ, Lee JW, Kang HR, Cho SH, Min KU, Chang YS.

Abstract
BACKGROUND: Recent literature suggests that Staphylococcal enterotoxin specific IgE may be a risk factor for asthma.
OBJECTIVE: To investigate the associations between Staphylococcal enterotoxin sensitization and asthma.
METHODS: A systematic review and meta-analysis was performed for relevant case-control or population-based studies, published in the peer-reviewed journals until February 2013. Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization.
RESULTS: A total of 683 studies were initially identified, of which 7 studies finally met the inclusion criteria (5 case-control and 2 population-based studies). All the included studies reported higher prevalence of the sensitization in asthmatics than in controls, despite clinical and methodological heterogeneity. In a meta-analysis, the pooled odds ratio of the sensitization for asthma was 2.95 (95% confidence intervals 2.28-3.82).
CONCLUSION: Staphylococcal enterotoxin sensitization was significantly associated with asthma. The mechanisms of associations warrant further elucidation.

Asia Pac Allergy. 2013 Apr;3(2):120-6. doi: 10.5415/apallergy.2013.3.2.120. Epub 2013 Apr 26.