哮喘联盟

   摘要
   通过临床症状、急性发作频率和肺功能来评估哮喘控制情况可能会受共病的影响，特别是慢性鼻窦炎 (CRS)的影响。测量鼻腔内一氧化氮(nNO)水平是一种评估CRS严重性的简单方法。我们旨在分析哮喘控制和nNO之间的关系。研究纳入从2009年11月至2010年4月，所有来我院门诊定期随访的中-重度哮喘患者，而且每位患者均进行了哮喘控制量表(ACQ)和共病（鼻炎、慢性鼻窦炎伴(CRSwNP)或不伴鼻息肉、肥胖）分析，并且记录呼出一氧化氮和nNO含量。最终纳入82例患者（平均年龄48岁,范围：21～80岁，女性42例）。根据ACQ评估，53例(64.6%)患者哮喘控制。哮喘未控制患者nNO水平更低，CRSwNP发生率更高，这与nNO和ACQ显著相关有关。nNO作为一种生物标志物与哮喘控制成负相关，正如低nNO值与CRSwNP相关一样。我们的研究结果表明，哮喘控制深受这种疾病的影响。
 

（苏楠 审校）
J Breath Res. 2013 May 10;7(2):026009. [Epub ahead of print]

 

Nasal nitric oxide is a marker of poor asthma control.
 

Heffler E, Pizzimenti S, Badiu I, Guida G, Ricciardolo FL, Bucca C, Rolla G.

Abstract
Asthma control, evaluated by symptoms, exacerbations rate and lung function may be greatly influenced by comorbidities, particularly chronic rhinosinusitis (CRS). Measurement of nasal nitric oxide (nNO) is a simple way to assess the severity of CRS. We aimed to analyze the relationship between asthma control and nasal NO. All patients with moderate-to-severe asthma on regular follow-up at our Outpatients' Clinic between November 2009 and April 2010 were included into the study. All patients were evaluated for asthma control by asthma control questionnaire (ACQ) and comorbidities (rhinitis, chronic rhinosinusitis with (CRSwNP) or without nasal polyps, obesity). Exhaled nitric oxide and nNO were obtained in all patients. Eighty-two patients were enrolled (mean age: 48 years, range: 21-80; 42 females). According to ACQ, 53 patients (64.6%) reported controlled asthma. Patients with uncontrolled asthma had lower nNO and higher prevalence of CRSwNP, with a significant correlation between nNO and ACQ. nNO is a biomarker negatively related to asthma control. As low nNO values were associated to CRSwNP, our results indicate that asthma control is highly influenced by this comorbidity.

J Breath Res. 2013 May 10;7(2):026009. [Epub ahead of print]