哮喘联盟

   摘要
   前言：气道炎症未得到最有效抑制是导致哮喘未控制的主要原因。在常规疗法中加入其它能够促进支气管扩张和/或减轻支气管炎症的药物，可能有助于改善疾病控制。噻托溴铵就是当前这样一种有待评估的潜在疗法。
   涉及领域：近期两项研究对噻托溴铵的长期疗效和安全性进行了评估，研究对象为经吸入糖皮质激素+长效β2受体激动剂治疗后哮喘控制差的患者。噻托溴铵能有效提高肺功能且疗效持久，并能降低急性发作风险（尤其是重度急性加重风险），但对改善症状和提高生活质量仅具有边际效应。
   专家意见：在治疗哮喘方面，吸入噻托溴铵能够促进支气管扩张，同时可能还具有抗炎作用。
 

（苏楠 审校）
Expert Opin Pharmacother. 2013 Mar 21. [Epub ahead of print]



 

Evaluation of inhaled tiotropium in asthma, uncontrolled with standard combination therapy.

Antoniu SA, Antohe I.

Source
University of Medicine and Pharmacy, Faculty of Medicine, Interdisciplinary Medicine, Department of Nursing , Grigore T Popa, 16 universitatii str 700115 , Iasi, Romania sabina.antonela.antoniu@pneum.umfiasi.ro.

Abstract
INTRODUCTION:  In uncontrolled asthma, the sub optimally inhibited airways inflammation is the main pathogenic event. Addition of other medications to the regular regimen might be able to improve disease control by enhancing bronchodilation and/or by reducing the bronchial inflammation. Tiotropium is currently under evaluation as a potential such therapy.
AREAS COVERED: The long-term efficacy and safety of tiotropium was recently evaluated in two studies in patients with poorly controlled asthma under inhaled corticosteroids + long-acting β2 agonists. Tiotropium was able to improve lung function and the effect was sustained, reduced the exacerbations risk (and in particular severe exacerbations risk), but had a marginal effect on symptoms and on quality of life.
EXPERT OPINION:  In asthma, inhaled tiotropium is able to increase the bronchodilation, and might also be able to exert an anti-inflammatory effect.
 

Expert Opin Pharmacother. 2013 Mar 21. [Epub ahead of print]