哮喘联盟

   摘要
   目的：分析获得与未获得哮喘缓解的两组哮喘患儿的特征。
   方法：该项回顾性队列研究所纳入的117例哮喘患儿来自于先前的一项研究。研究者将儿童分为两组：哮喘缓解组和哮喘未缓解组。哮喘缓解定义为至少连续3年无哮喘症状/体征或无需哮喘相关性的药物治疗或医疗服务。长期缓解定义为缓解后哮喘无复发。同时分析各组患儿的特征。
   结果：117例受试者中70例（60%）为男性，91例（78%）为白种人，哮喘发病的平均年龄为8.1岁。共有59例(50%)哮喘患儿获得缓解，28例(24%)获得长期缓解。相比哮喘未缓解组的患儿，哮喘缓解组的患儿大部分是白种人(69% vs 87%, p=0.039)。哮喘缓解和未缓解组患儿因病毒感染(0.3 vs. 0.4 每人/年, p=0.29)或细菌感染(0.7 vs. 0.5每人/年, p=0.49)导致的住院频率无显著差异。性别、社会经济地位、烟草烟雾暴露情况、哮喘或特异性疾病家族史、母乳喂养史、峰流速仪的利用率、哮喘控制计划以及流感疫苗接种均与哮喘缓解无相关性。
   结论：仅半数哮喘患儿曾获得缓解、24%获得长期缓解。哮喘缓解可能会受种族特征影响，而不受微生物感染的影响，反之亦然。
 

（刘国梁 审校）
J Asthma. 2013 Mar 20. [Epub ahead of print]
 

Characteristics of Children with Asthma who Achieved Remission of Asthma.
 

Javed A, Yoo KH, Agarwal K, Jacobson RM, Li X, Juhn YJ.

Source
Department of Pediatric and Adolescent Medicine, Mayo Clinic , Rochester, MN.

Abstract
OBJECTIVE: To characterize two groups of asthmatics who had achieved remission and those who had not achieved remission of asthma.
METHODS: The study was a retrospective cohort study based on 117 asthmatic children who participated in a previous study. We categorized the children into 2 groups: asthmatics with remission vs. asthmatics without remission. We defined remission of asthma as lack of symptoms/signs of asthma or asthma-related medications or health care services for at least 3 consecutive years. Long-term remission was defined by no relapse of asthma after achieving remission. We characterized these groups.
RESULTS:Of the 117 subjects, 70 (60%) were male, 91 (78%) were Caucasians, and the mean age at index date of asthma was 8.1 years. A total of 59 asthmatic children (50%) achieved remission and 28 asthmatics (24%) achieved long-term remission. Asthmatics with remission were more likely to be Caucasian (87%) compared to those without (69%) (p=0.039) There were no differences in the frequency of visits for viral (0.3 vs. 0.4 per person-years, p=0.29) or bacterial infections (0.7 vs. 0.5 per person-years, p=0.49) between asthmatics with and without remission. Gender, socioeconomic status, smoking exposure, family history of asthma or atopy, breastfeeding history, peak flow meter availability, asthma action plan, and influenza vaccinations were not associated with remission.
CONCLUSIONS:Only half of asthmatic children accomplished remission of asthma ever and 24% of asthmatic children had long-term remission. Ethnicity may affect remission of asthma but microbial infections may not influence the likelihood of remission of asthma and vice versa.
 

J Asthma. 2013 Mar 20. [Epub ahead of print]