慢性咳嗽的治疗：治疗咽喉对粘液的感觉
2013/04/19
摘要
咳嗽相关的咽喉对粘液的感觉（SMIT）常常被忽视，因为体检和咳嗽特异性问卷调查并未涉及该方面。我们的研究结果显示，SMIT能预测慢性咳嗽患者中是否存在真菌定植。我们认为，SMIT是继咳嗽和痰液之后的第三个关键性临床症状，可用于预测慢性咳嗽患者抗真菌治疗的疗效。Ryan及其同事(1)近期的研究报道，卡巴喷丁可作为一种新型止咳药，对中枢反射致敏症状有较好的疗效，后者被认为是慢性咳嗽的一个潜在机制。他们的研究显示，与无中枢致敏（CS）的个体相比，中枢致敏（包括咽喉感觉异常）的个体对卡巴喷丁治疗应答增加。然而，咽喉功能异常问卷调查的平均评分在治疗期内无改善。这表明存在一些不能被该药抑制的咽喉感觉。
(林江涛 审校)
Respirology. 2013 Feb 19. doi: 10.1111/resp.12064. [Epub ahead of print]
Chronic cough management: dealing with a sensation of mucus in the throat.
Ogawa H, Fujimura M, Takeuchi Y, Makimura K.
Source
Division of Pulmonary Medicine, Ishikawa-ken Saiseikai Kanazawa Hospital, Kanazawa, Japan.
Abstract
The cough-related laryngeal sensation of mucus in the throat (SMIT) is usually overlooked because it is not reflected by physiological examinations or cough-specific questionnaires. Our results suggested that SMIT can predict the presence of fungal colonization in chronic cough patients. We propose that, next to "cough" or "sputum," SMIT may become the third key clinical symptom for predicting the efficacy of antifungal therapy in chronic cough patients. Ryan and colleagues (1) recently reported gabapentin to be a novel antitussive with a beneficial effect against symptoms of central reflex sensitization, the latter of which is considered to be a potential mechanism underlying chronic cough. Their study showed that subjects with central sensitization (CS), including abnormal laryngeal paresthesia, had an enhanced response to gabapentin compared to those without CS. However, the mean laryngeal dysfunction questionnaire score did not improve during the treatment period. This suggests the presence of some laryngeal sensations that are not suppressed by this drug.
Respirology. 2013 Feb 19. doi: 10.1111/resp.12064. [Epub ahead of print]
