哮喘联盟

   摘要
   目的：血管性水肿和咳嗽是ACE抑制剂（ACEI）最重要的不良反应。有证据显示，ACEI相关的血管性水肿和咳嗽与遗传因素有关，一些基因被发现可在ACEI相关性不良反应的发生中起到重要作用。
   材料和方法：本试验旨在评价这些遗传相关性的证据和ACEI的不良反应。在去除重复研究和临床评价之外，对19项研究进行总结分析。14项研究与咳嗽有关，5项研究于血管性水肿有关。采用独立的荟萃分析研究ACE插入/缺失多态性（rs4646994）及其与咳嗽的关系。
   结果和结论：在3项研究中，一个基因区（XPNPEP2）与ACEI诱导的血管性水肿相关。本项荟萃分析并未发现ACE插入/缺失多态性与ACEI咳嗽显著相关。

 

(林江涛 审校)
Pharmacogenomics. 2013 Feb;14(3):249-60. doi: 10.2217/pgs.12.206.

 

Pharmacogenetics of ACE inhibitor-induced angioedema and cough: a systematic review and meta-analysis.
 
Mahmoudpour SH, Leusink M, Putten Lv, Terreehorst I, Asselbergs FW, de Boer A, Maitland-van der Zee AH.

Source
Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

Abstract 
AIM: Angioedema and cough are the two most important adverse effects of ACE inhibitors (ACEIs). Evidence exists that ACEI-related angioedema/cough is partly genetically determined and several genes have been identified to play a role in the development of ACEI-related adverse effects.
MATERIALS & METHODS: This study was performed in order to evaluate the evidence of these genetic associations and ACEIs' adverse effects. After removing duplicates and critical appraisal, 19 studies were considered to be eligible to review; 14 articles about cough and five articles about angioedema. A separate meta-analysis was performed for the most studied ACE insertion/deletion polymorphism (rs4646994) and its association with cough.
RESULTS & CONCLUSION: One gene region (XPNPEP2) was associated with ACEI-induced angioedema in three studies. In our meta-analysis we did not find a significant association between the ACE insertion/deletion polymorphism and ACEI cough.
 

Pharmacogenomics. 2013 Feb;14(3):249-60. doi: 10.2217/pgs.12.206.