哮喘联盟

   摘要
   摘要：本试验在伴有抑郁症的哮喘患者中研究气道炎症和下丘脑-垂体-肾上腺轴（HPAA）活性的特征。
   方法：成人哮喘患者入选本研究，基于Hamilton抑郁评分量表（HAMD）将患者分为两组：伴抑郁症的哮喘患者（HAMD评分≥8, n=23）和无抑郁症的哮喘患者（HAMD<8, n=41）。此外，27名健康受试者和21名仅有抑郁症的成人患者作为对照者入选。收集诱导痰液和血液样本，检测细胞因子和其他炎症因子。检测唾液可的松和其他激素的日间节律以评价HPAA活性。
   结果：患有抑郁症的哮喘患者，平均HAMD评分为19.0；无抑郁症的哮喘患者，HAMD评分为4.9(P<0.001)。患有抑郁症的哮喘患者，血清和痰液肿瘤坏死因子 (TNF-α)水平显著高于其他组(P<0.05)；而患有抑郁症的哮喘患者，血清干扰素 (IFN-γ)显著低于其他组(P<0.05)。患有抑郁症的哮喘患者，24 h尿可的松、早上8点和下午4点的唾液可的松水平显著低于其他组(P<0.05)。
   结论：与健康受试者、哮喘患者或抑郁症患者相比，同时患有抑郁症和哮喘的患者的促炎细胞因子水平最高，而抗炎细胞因子和可的松水平最低。这些结果可作为哮喘患者抑郁症诊断和临床治疗一个有价值的参考。

（苏楠 审校）
J Asthma. 2013 Jan 17. [Epub ahead of print]

 

Airway Inflammation and Hypothalamic-Pituitary-Adrenal Axis Activity in Asthmatic Adults With Depression.
 
Du YJ, Li B, Cao YX, Dong JC.

Source
Lab of Integrative Medicine for Lung, Inflammation and Cancers, Huashan Hospital, Fudan University , Shanghai , China.

Abstract 
OBJECTIVE: To investigate the features of airway inflammation and hypothalamic-pituitary-adrenal axis (HPAA) activity in patients with asthma accompanied by depression.
METHODS: Adult asthmatics were recruited and enrolled into one of two groups based on scores on the Hamilton Depression Rating Scale (HAMD): asthmatics with depression (HAMD score ≥8, n=23), and asthmatics without depression (HAMD score <8, n=41). In addition, 27 healthy individuals and 21 adults with depression only were enrolled as controls. Induced sputum and blood samples were collected for measurement of cytokines and other inflammatory factors. The diurnal rhythm profiles of salivary cortisol and other hormones were obtained for assessment of the HPAA activity.
RESULTS: For the group of asthmatics with depression, the mean HAMD score was 19.0, and for the group of asthmatics without depression, the HAMD score averaged 4.9(P<0.001). Serum and sputum tumor necrosis factor alpha (TNF-α) were significantly higher in asthmatics with depression than those in the other groups (P<0.05) while serum interferon gamma (IFN-γ) was lower in asthmatics with depression than that in the other groups (P<0.05). 24 h urinary cortisol, salivary cortisol at 8 a.m. and 4 p.m. were lower in asthmatics with depression compared to other groups (P<0.05).
CONCLUSIONS: As compared to healthy individuals and those with asthma or depression alone, individuals with comorbid depression and asthma showed the highest level of pro-inflammatory cytokines and the lowest level of anti-inflammatory cytokines and cortisol. These observations may serve as a valuable reference for diagnosis and clinic therapies of depression in asthmatics.

J Asthma. 2013 Jan 17. [Epub ahead of print]