美国年轻成人摄入长链omega-3(n-3)多不饱和脂肪酸PUFA和鱼类与哮喘发生的关系:CARDI
2012/12/31
摘要
背景:虽然研究发现,长链ω-3(n-3)PUFAs(LCω3PUFAs)摄入能预防一些炎症性疾病,有关LCω3PUFAs与哮喘发病之间的关系,目前了解甚少。
目的:本试验在美国年轻成人中前瞻性研究LCω3PUFAs和鱼类摄入与哮喘发生之间的关系。
设计:对4162名双人种美国人(18~30岁)进行20年的纵向随访分析,这些受试者在基线状态下(1985年)均有哮喘病史。于1985年、1992年和2005年,采用经过验证的定量食物频率问卷,通过访谈进行调查。自我主诉的哮喘定义为1985年~2005年间医生诊断的哮喘和哮喘药物治疗。
结果:为期20年的随访中,发现446名哮喘病例。经社会人口统计学、主要生活方式和饮食混杂因素校正后,LCω3PUFA摄入与哮喘发生成显著负相关。与LCω3PUFA摄入最低的五分位数相比,LCω3PUFA摄入最高的五分位数,其多变量校正的HR为0.46(95% CI: 0.33, 0.64; P趋势 < 0.01)。然而,非油炸鱼摄入频率较高与哮喘风险无显著相关性。DHA与哮喘风险的负相关,强于EPA与哮喘风险的相关性。性别、种族、BMI、吸烟状态和特应性状态不能改变LCω3PUFA与哮喘发生的关系。
结论:美国年轻成人中,LCω3PUFA摄入与哮喘发生成负向、纵向相关。
(林江涛 审校)
Am J Clin Nutr. 2012 Nov 28. [Epub ahead of print]
Intakes of long-chain omega-3 (n-3) PUFAs and fish in relation to incidence of asthma among American young adults: the CARDIA study.
Li J, Xun P, Zamora D, Sood A, Liu K, Daviglus M, Iribarren C, Jacobs D Jr, Shikany JM, He K.
Source
Departments of Epidemiology and Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Abstract
BACKGROUND: Although long-chain ω-3 (n-3) PUFAs (LCω3PUFAs) have been linked to the prevention of some inflammatory disorders, little is known about the association between these fatty acids and incidence of asthma.
OBJECTIVE: The objective was to prospectively investigate the association between LCω3PUFAs and fish intake and incidence of asthma among American young adults.
DESIGN: A 20-y follow-up longitudinal analysis was conducted in a biracial cohort of 4162 Americans, aged 18-30 y, with a history of asthma at baseline in 1985. Diet was assessed by a validated interviewer-administered quantitative food-frequency questionnaire at the examinations in 1985, 1992, and 2005. Incident self-reported asthma was defined as having a physician diagnosis of asthma and/or the use of asthma medications between 1985 and 2005.
RESULTS: During the 20-y follow-up, 446 incident cases of asthma were identified. LCω3PUFA intake was significantly inversely associated with incidence of asthma after adjustment for sociodemographic, major lifestyle, and dietary confounders. The multivariable-adjusted HR for the highest quintile of LCω3PUFA intake as compared with the lowest quintile was 0.46 (95% CI: 0.33, 0.64; P-trend < 0.01). However, a higher frequency of nonfried fish consumption was not significantly associated with the risk of asthma. DHA showed a greater inverse association than did EPA. The association between LCω3PUFAs and incident asthma was not appreciably modified by sex, race, BMI, smoking status, or atopic status.
CONCLUSION: This study showed that intakes of LCω3PUFAs are inversely longitudinally associated with the incidence of asthma in American young adults.
Am J Clin Nutr. 2012 Nov 28. [Epub ahead of print]
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基于人群的出生体重和哮喘风险相关性研究:倾向评分法
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1993年至2007年西班牙加利西亚省哮喘死亡率趋势