抗氧化剂摄入和儿童过敏性疾病
2012/11/19
摘要
背景：抗氧化剂摄入可以通过保护组织免受氧化损伤来降低过敏性疾病风险。西方国家人群抗氧化剂的主要来源是水果、蔬菜（维生素C、β-胡萝卜素、α-生育酚）、肉类和牛奶（硒、镁和锌）。由于花粉和这些食物可能存在交叉反应，儿童不吃或很少吃蔬菜和水果，可导致对其因果关系的评价变得复杂。
目的：研究饮食抗氧化剂摄入和过敏性疾病发生的相关性，并考虑到潜在的反向因果联系。
方法：收集瑞典出生队列研究BAMSE中2442名8岁儿童的信息。父母完成有关暴露和健康相关的问卷调查（包括食物食用频率问卷调查）以及提供血液样本的父母，其家庭儿童入选本研究。采用logistic回归分析过去一年抗氧化剂摄入与当前过敏性疾病的关系。
结果：β-胡萝卜素的摄入和鼻炎之间存在负相关（校正后OR：最高 vs 最低四分位间距，0.67, 95% CI 0.49-0.93）。镁的摄入与哮喘（校正后OR：0.65, 95% CI 0.42-1.00）和过敏性致敏（校正后OR：0.78, 95% CI 0.61-1.00）呈负相关。对某些水果、蔬菜和牛奶过敏（过敏性症状）的儿童（n = 285）排除之后，镁的摄入与哮喘呈负相关（校正后OR：0.58, 95% CI 0.35-0.98），但所有相关性无显著性。
结论和临床意义：由于过敏症导致饮食调整会影响抗氧化剂的摄入，在研究饮食与过敏性疾病相关性时需考虑上述情况。镁的摄入似乎对儿童期哮喘具有保护作用。
（林江涛 审校）
Clin Exp Allergy. 2012 Oct;42(10):1491-500. doi: 10.1111/j.1365-2222.2012.04053.x.
Antioxidant intake and allergic disease in children.
Rosenlund H, Magnusson J, Kull I, Håkansson N, Wolk A, Pershagen G, Wickman M, Bergström A.
Source
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden.
Abstract
BACKGROUND: Antioxidant intake may reduce the risk of allergic disease by protecting against oxidative tissue damage. Major sources of antioxidants in the Western world are fruits, vegetables (vitamin C, β-carotene, α-tocopherol), meat and milk (selenium, magnesium, zinc). Children may exclude or eat less of some fruits and vegetables due to cross-reactivity between pollen and these foods, complicating assessment of causal relationships.
OBJECTIVE: To investigate the association between dietary antioxidant intake and allergic disease, taking potential reverse causation into account.
METHODS: Data on 2442 8-year-old children from the Swedish birth cohort study BAMSE were analysed. Children with completed parental questionnaires on exposures and health, including a food-frequency questionnaire and who provided a blood sample were included. Associations between antioxidant intake during the past year and current allergic disease were analysed using logistic regression.
RESULTS: An inverse association was observed between intake of β-carotene and rhinitis (OR(adj) , highest vs. lowest quartile, 0.67, 95% CI 0.49-0.93). Magnesium intake was inversely related to asthma (OR(adj) , 0.65, 95% CI 0.42-1.00) and atopic sensitisation (OR(adj) , 0.78, 95% CI 0.61-1.00). Following exclusion of children who avoided certain fruits, vegetables or milk due to allergic symptoms (n = 285), the inverse association remained between magnesium intake and asthma (OR(adj) , 0.58, 95% CI 0.35-0.98), whereas all other associations became non-significant.
CONCLUSION AND CLINICAL RELEVANCE: Diet modifications due to allergy may affect the antioxidant intake and needs to be considered when investigating the relationship between diet and allergic disease. Magnesium intake seems to have a protective effect on childhood asthma.
Clin Exp Allergy. 2012 Oct;42(10):1491-500. doi: 10.1111/j.1365-2222.2012.04053.x.
