干扰素调节因子5基因多态性与哮喘的关系
2012/07/05
摘要
哮喘是一种异质性疾病，主要表现为呼吸系统慢性炎症。哮喘发作与呼吸道感染相关。干扰素调节因子5（IRF5）参与了先天性和获得性免疫。本试验在2个哮喘家庭队列中研究IRF5的10个基因多态性优先传递模式。结果显示，一个常见的IRF5单体与哮喘和哮喘症状严重程度相关。对哮喘患者进行分层分析显示，这些相关性在非过敏性哮喘患者更明显。此外，IRF5多态性等位基因与哮喘风险的关系，和其与自身免疫性疾病的关系完全相反。本研究首次发现IRF5与哮喘相关，IRF与哮喘和自身免疫性疾病均相关，但在两者中的作用不同。
（苏楠 审校）
Gene. 2012 May 18. [Epub ahead of print]
Gene. 2012 May 18. [Epub ahead of print]
Wang C, Rose-Zerilli MJ, Koppelman GH, Sandling JK, Holloway JW, Postma DS, Holgate ST, Bours V, Syvänen AC, Dideberg V.
Source
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Abstract
Asthma is a heterogeneous disorder hallmarked by chronic inflammation in the respiratory system. Exacerbations of asthma are correlated with respiratory infections. Considering the implication of interferon regulatory factor 5 (IRF5) in innate and adaptive immunity, we investigated the preferential transmission patterns of ten IRF5 gene polymorphisms in two asthmatic family cohorts. A common IRF5 haplotype was found to be associated with asthma and the severity of asthmatic symptoms. Stratified analysis of subgroups of asthmatic individuals revealed that the associations were more pronounced in nonatopic asthmatic individuals. In addition, the risk alleles of IRF5 polymorphisms for asthma were almost completely opposite to those for autoimmune disorders. Our study provides the first evidence of association between IRF5 and asthma, and sheds light on the related but potentially distinct roles of IRF5 alleles in the pathogenesis of asthma and autoimmune disorders.
Gene. 2012 May 18. [Epub ahead of print]
