母亲孕期进食与子女哮喘和过敏性疾病的相关性：来自芬兰的出生队列研究
2012/05/08
背景：流行病学和免疫学研究显示，母亲孕期的饮食可能会影响子女过敏性疾病的发生。本试验旨在研究母亲孕期饮食对子女5岁时基于儿童哮喘和过敏症国际研究（ISAAC）的过敏性疾病（哮喘、过敏性鼻炎和喘息）转归的影响。
方法：入选芬兰1型糖尿病预测和预防（DIPP）饮食研究中的2441名5岁儿童，并对数据进行分析，前述研究为一项以人群为基础的、出生队列研究。母亲饮食采用有效的食物频率问卷调查进行评价。
结果：在对已知的混杂因素校正后，多元回归模型显示，母亲绿叶蔬菜食用过少（校正后优势比[aOR]：1.55; 95% CI: 1.21, 1.98）、苹果食用过少（aOR: 1.45; 95% CI: 1.15, 1.84）和巧克力食用过少（aOR: 1.36; 95% CI: 1.09, 1.70）与儿童喘息风险成正相关。母亲孕期食用水果和浆果果汁较多，与儿童过敏性鼻炎风险成正相关（aOR: 1.40; 95% CI: 1.03, 1.90）。未观察到孕期饮食与哮喘的相关性。
结论：学龄前儿童过敏性疾病的发生受到其在子宫内时母亲饮食的影响。
（刘国梁 审校）
PediatrAllergyImmunol.2012Mar;23(2):186-194.doi:10.1111/j.1399-3038.2012.01272.x.
Risk of asthma and allergic outcomes in the offspring in relation to maternal food consumption during pregnancy: A Finnish birth cohort study.
Erkkola M, Nwaru BI, Kaila M, Kronberg-Kippilä C, Ilonen J, Simell O, Veijola R, Knip M, Virtanen SM.
Source
Division of Nutrition, Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland Tampere School of Health Sciences, University of Tampere, Finland Department of Pediatrics, Tampere University Hospital, Tampere, Finland Nutrition Unit, Department of Lifestyle and Participation, National Institute of Health and Welfare, Helsinki, Finland Immunogenetics Laboratory, 20014 University of Turku, Turku, Finland Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland Department of Pediatrics, University of Turku, Turku, Finland Department of Pediatrics, University of Oulu, Oulu, Finland Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland Folkhälsan Research Institute, Helsinki, Finland Science Center of Pirkanmaa Hospital District, Tampere, Finland.
Abstract
BACKGROUND: Epidemiological and immunological studies suggest that maternal diet during pregnancy might affect the development of allergic diseases in the offspring. The authors set out to study the effect of maternal food consumption during pregnancy on the emergence of the International Study of Asthma and Allergies in Childhood (ISAAC)-based allergic outcomes: asthma, allergic rhinitis, and wheeze by the 5 yr of age.
METHODS:Data from 2441 children at 5 yr of age were analyzed within the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study, a population-based birth cohort study. Maternal diet was assessed with a validated food frequency questionnaire.
RESULTS:In multiple regression models adjusted for known confounders, low maternal consumption of leafy vegetables (adjusted odds ratio [aOR]: 1.55; 95% CI: 1.21, 1.98), malaceous fruits (aOR: 1.45; 95% CI: 1.15, 1.84), and chocolate (aOR: 1.36; 95% CI: 1.09, 1.70) were positively associated with the risk of wheeze in children. High maternal consumption of fruit and berry juices was positively associated with the risk of allergic rhinitis (aOR: 1.40; 95% CI: 1.03, 1.90) in children. No associations were observed between maternal food consumption and asthma.
CONCLUSIONS: Development of allergic diseases in preschool children may be influenced by intrauterine exposure to maternal diet.
PediatrAllergyImmunol.2012Mar;23(2):186-194.doi:10.1111/j.1399-3038.2012.01272.x.
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产前和被动烟雾暴露和哮喘及喘息的发病率：系统综述和荟萃分析
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2002～2007年爱尔兰学龄期儿童哮喘、过敏性鼻炎和湿疹患病率趋势
