筛查存在运动诱发支气管收缩的大学生运动员
2012/04/06
目的:前期研究显示,运动员中运动诱发的支气管收缩(EIB)发生率高于普通人群。越来越多的研究显示,运动员未能识别和主诉EIB的症状。因此,对于是否有必要在运动员中筛查EIB存在着争议,特别是那些高危运动项目运动员。
方法:在一项全国大学生体育协会部I大学生体育计划研究中,我们对来自6个不同项目的144名运动员进行前瞻性研究。收集基础水平人口统计学资料和病史,记录运动时出现的哮喘症状。每名运动员随后接受血碳酸正常的自主过度通气(EVH)测试,观察是否出现EIB。在EVH前即刻检测呼出气一氧化氮含量(eNO)。EIB定义为第一秒用力呼气容积比基础水平下降≥10%。
结果:EVH 测试显示,144名运动员中有4名(2.7%)EIB阳性。哮喘症状的出现对EIB无预测性,因为64名有症状的运动员中仅2名(3%)在EVH测试中表现为阳性。4名EIB阳性的运动员中,有2名否认哮喘症状。4名EIB阳性运动员的平均基础FeNO为13.25 ppb,而EIB阴性运动员为24.5 ppb。
结论:我们研究结果显示,不推荐对运动员进行EIB筛查,因为本研究显示的EIB发生率在运动员中非常低。此外,是否出现哮喘症状,不能预测EIB,FeNO也不是预测EIB的一个有效手段。
(苏楠 审校)
J Asthma. 2012 Mar;49(2):153-7. Epub 2012 Jan 25.
Screening for exercise-induced bronchoconstriction in college athletes.
Parsons JP, Cosmar D, Phillips G, Kaeding C, Best TM, Mastronarde JG.
Source
Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, The Ohio State University Medical Center , Columbus, OH , USA.
Abstract
OBJECTIVE:Previous studies have reported that the prevalence of exercise-induced bronchoconstriction (EIB) in athletes is higher than that of the general population. There is increasing evidence that athletes fail to recognize and report symptoms of EIB. As a result, there has been debate whether athletes should be screened for EIB, particularly in high-risk sports.
METHODS:We prospectively studied 144 athletes from six different varsity sports at a large National Collegiate Athletic Association Division I collegiate athletic program. Baseline demographics and medical history were obtained and the presence of asthma symptoms during exercise was documented. Each athlete subsequently underwent a eucapnic voluntary hyperventilation (EVH) test to document the presence of EIB. Exhaled nitric oxide (eNO) quantification was performed immediately before EVH testing. EIB was defined as a ≥10% decline in forced expiratory volume in 1 second compared with baseline.
RESULTS:Only 4 of 144 (2.7%) athletes were EIB-positive after EVH testing. The presence of symptoms was not predictive of EIB as only 2 of the 64 symptomatic athletes (3%) were EIB-positive based on EVH testing. Two of the four athletes who were found to be EIB-positive denied such symptoms. The mean baseline eNO in the four EIB-positive athletes was 13.25 parts per billion (ppb) and 24.5 ppb in the EIB-negative athletes.
CONCLUSIONS:Our data argue that screening for EIB is not recommended given the surprisingly low prevalence of EIB in the population we studied. In addition, the presence or absence of symptoms was not predictive of EIB and eNO testing was not effective in predicting EIB.
J Asthma. 2012 Mar;49(2):153-7. Epub 2012 Jan 25.
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无哮喘症状患者对呼吸困难的敏感性与呼气峰流速波动的关系
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过敏性哮喘患者过敏原吸入激发后外周血基因表达变化