环境干预对儿童支气管哮喘屋尘螨的控制
2012/03/06
摘要
研究目的：通过物理和化学的方法来控制环境中的屋尘螨，来确定环境干预在控制儿童支气管哮喘中的作用。
研究方法：选取160名对屋尘螨过敏的哮喘患儿进行临床和环境的评估，根据干预方法的不同将其随机分配到四组（化学干预组，物理干预组，重叠干预组，无干预组），在研究的第8和16周进行效果评估。
研究结果：在所有分组中，采用物理方法干预的一组的结果改善最好，包括第一秒用力呼气量(FEV1)和最大呼气流速(PEFR)，在第8周的随访评估中分别是2.05%和4.65L/min。重度哮喘的百分率从45%降至22%。在重叠干预组，即同时应用化学（鞣酸）和物理干预方法，也取得类似改善结果(p<0.05)。在化学（鞣酸）干预组中，中度和重度哮喘患儿的数量分别都从15降至11和7。在采取环境干预16周后，只有平均最大呼气流速(1.62L/min)具有明显改善。尽管这些研究结果都有改善，但进行四组比较时，只有第一秒用力呼气量(FEV1)具有明显差异。
研究结论：以上我们总结出，通过单纯的物理方法对环境进行干预对屋尘螨过敏的哮喘患儿的病情控制有潜在的帮助。
（谢萌 首都儿科研究所 哮喘中心 100020摘译）
Environ Health Prev Med. 2012 Feb 3. [Epub ahead of print]
Environmental intervention for house dust mite control in childhood bronchial asthmaEl-Ghitany EM, Abd El-Salam MM.
Source：
Tropical Health Department, High Institute of Public Health, Alexandria University, 165 El Horreya Avenue, Alexandria, Egypt, ingy
Tropical Health Department, High Institute of Public Health, Alexandria University, 165 El Horreya Avenue, Alexandria, Egypt, ingy
Abstract：
OBJECTIVES: This study was carried out to determine the effectiveness of physical and chemical environmental control measures for house dust mites (HDM) in controlling bronchial asthma in children.
METHODS: A total of 160 asthmatic children who were sensitized to HDM underwent clinical and environmental assessment. The children were randomly allocated into one of four groups according to the intervention (chemical, physical, both chemical and physical, none) and the effectiveness of the intervention was assessed at 8 and 16 weeks.
RESULTS: The group for which physical control measures were used showed significant improvement in all outcome measures, including mean differences of forced expiratory volume after 1 s (FEV1) and peak expiratory flow rate (PEFR), which were 2.05% and 4.65?l/min, respectively, at the 8-week follow-up evaluation. The percentage of severe asthma decreased from 45 to 22%. Similar results were obtained for the group with both chemical (tannic acid) and physical interventions (p?
CONCLUSIONS: Based on these results, we conclude that simple physical control measures have the potential to contribute to the control of asthma symptoms in asthmatic children sensitized to HDM allergen.
Environ Health Prev Med. 2012 Feb 3. [Epub ahead of print]
上一篇：
倍氯米松/福莫特罗与丙酸氟替卡松/沙美特罗治疗中度至重度哮喘的成本-效益和成本-效用分析
下一篇：
母亲哮喘对围产期转归的影响：2阶段取样队列研究
