日本成人体重指数与哮喘的关系:正常体重指数成人的哮喘风险
2012/01/31
摘要
背景:越来越多的数据显示,与西方人群相比,一些亚洲人容易出现体重增加及非传染性疾病。然而,有关亚洲人群体重增加(特别是正常范围内的增加)与哮喘发生之间的关系了解较少。
方法:在日本成人中研究体重指数(BMI)增加与哮喘的关系。数据来自于日本全国人群为基础的哮喘患病率横断面研究(22962名受试者,年龄20~79岁)。基于WHO推荐标准,将BMI分为7类(截止值分别为:17.00、18.50、23.00、25.00、27.50和30.00)。BMI与哮喘患病和哮喘症状的关系通过多变量logistic回归分析。
结果:肥胖患病率(BMI ≥30.00)相对较低(男:3.0%;女性:2.3%)。与参考人群(BMI 18.50-22.99)相比,男性和女性BMI≥25.00与哮喘风险增加相关。即使女性BMI为23.00-24.99,与参考组相比,哮喘患病率仍然显著增加(校正后优势比:1.49;95%可信区间:1.16-1.92)
结论:日本女性哮喘患病率增加开始于BMI=23.0,该值低于西方人群的截止值。该结果显示,与西方人群相比,日本哮喘易感人群的肥胖程度更轻。
(刘国梁 审校)
Int Arch Allergy Immunol. 2011 Oct 28;157(3):281-287. [Epub ahead of print]
Association between Body Mass Index and Asthma among Japanese Adults: Risk within the Normal Weight Range.
Fukutomi Y, Taniguchi M, Nakamura H, Konno S, Nishimura M, Kawagishi Y, Okada C, Tanimoto Y, Takahashi K, Akasawa A, Akiyama K.
Source
Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan.
Abstract
BACKGROUND: Increasing amounts of data have shown that some Asian populations are more susceptible to increased weight and development of noncommunicable disease than Western populations. However, little is known about the association between increased weight, particularly within the normal range, and the development of asthma among Asian populations.
METHODS: To examine the association between increased body mass index (BMI) and asthma among Japanese adults, data from a nationwide population-based cross-sectional survey of asthma prevalence in Japan were analyzed (n = 22,962; age range 20-79 years). BMIs were classified into 7 categories considering WHO recommendations (cutoff points: 17.00, 18.50, 23.00, 25.00, 27.50 and 30.00), and the association between BMI and the prevalences of asthma as well as asthma symptoms were assessed by multivariate logistic regression.
RESULTS: The prevalences of obesity (BMI ≥30.00) in this population were relatively low (males 3.0%, females 2.3%). BMI categories of 25.00 or higher in both genders were significantly associated with an increased risk of asthma compared with the reference category (BMI 18.50-22.99). Even in females with a BMI of 23.00-24.99, the prevalence of asthma significantly increased (adjusted odds ratio 1.49, 95% confidence interval 1.16-1.92) compared with that in the reference category.
CONCLUSIONS: An increase in the prevalence of asthma among Japanese females starts at a BMI of 23.00, which was relatively lower than those reported from Western countries. This finding suggests that the Japanese population is likely to have asthma with a lesser degree of obesity than Western populations.
Int Arch Allergy Immunol. 2011 Oct 28;157(3):281-287. [Epub ahead of print]
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