法国青少年哮喘与严重抑郁发作的关系
2011/08/12
摘要
原理:对青少年哮喘与焦虑之间的关系已经进行充分研究,但对哮喘与情绪障碍相关性的数据较为缺乏。
方法:在此项横断面研究中,我们对来自法国2003年至2004年9年级学龄期儿童的数据进行分析。通过2级抽样进行青少年的选择,采用标准的问卷调查(有关哮喘和哮喘样症状),通过校医和护士进行面谈。同时,研究对象完成自填问卷调查,调查内容包括过去12个月内的重度抑郁发作(MDEs),后者通过复合国际诊断访谈-简表评价。
结果:共计7000名青少年入选研究,平均年龄15.1岁。过去12个月内的喘息发生率为10%,当前哮喘(过去12个月内喘息儿童有哮喘发作、或过去12个月内因喘息或哮喘进行治疗)发生率为8.5%。过去1年内MDE的发生率,在当前哮喘患者为14.2%,其他研究对象为9.2%。在经年龄、性别、家庭结构和父亲工作状态校正后,当前哮喘与过去1年MDE之间存在显著相关性。哮喘未控制定义为喘息发作4次、每周因为喘息而觉醒1次、1次严重喘息、4次计划外医院就诊、1次因喘息发作住院。有MDE的哮喘患者,在过去1年中有超过1半的患者(58.3%)哮喘未得到控制,而无MDE的哮喘患者为35.3%。
结论:青少年哮喘患者具有较高的MDE发生率。在哮喘青少年患者中,MDE与哮喘控制较差相关。这些结果表明,在对法国青少年哮喘患者的综合治疗中,有必要考虑心理状态。
(刘国梁 审校)
J Asthma. 2011 May 25. [Epub ahead of print]
Asthma and Major Depressive Episode in Adolescents in France.
Delmas MC, Guignon N, Chan Chee C, Fuhrman C, Herbet JB, Gonzalez L.
Source
Institut de Veille Sanitaire , Saint-Maurice , France .
Abstract
RATIONALE: The association between asthma and anxiety disorders in teenagers is well documented, but data about the association with mood disorders are scarce.
METHODS: We analyzed data from a cross-sectional study conducted among ninth grade schoolchildren in France in 2003-2004. The teenagers were selected by two-stage sampling and interviewed by school doctors/nurses using a standardized questionnaire including questions about asthma and asthma-like symptoms. They also completed a self-administered questionnaire in which the occurrence of major depressive episodes (MDEs) during the past 12 months was assessed by the Composite International Diagnostic Interview-Short Form.
RESULTS: A total of 7000 teenagers (mean age 15.1 years) were included. The prevalence of wheezing in the past 12 months was 10.0% and that of current asthma (wheezing in the past 12 months in children who had already had asthma attacks, or treatment for wheezing or asthma in the past 12 months) was 8.5%. The prevalence of MDE during the past year was 14.2% in teenagers with current asthma versus 9.2% among the others. The association between current asthma and past-year MDE remained significant after adjustment for age, gender, family structure, and the father’s employment status. Asthma was uncontrolled (at least four attacks of wheezing, one awakening per week due to wheezing, one severe wheezing, four unplanned medical visits, or one hospitalization for a wheezing attack in the past year) in more than half (58.3%) of asthmatic teenagers with an MDE in the past year versus 35.3% of those without an MDE.
CONCLUSION: Asthma is associated with a higher prevalence of MDE. Among adolescents with asthma, MDE is associated with poorer asthma control. These findings highlight the need for a comprehensive care management of asthma in France that takes the psychological dimension into account.
J Asthma. 2011 May 25. [Epub ahead of print]
上一篇:
氢氟烷-倍氯米松超细颗粒和大颗粒在哮喘控制中的作用:现实条件下的观察性研究
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