白三烯受体拮抗剂联合吸入激素治疗能改善支气管哮喘患者的生命质量:来自日本东京郊区的调查
2011/08/12
摘要
背景:支气管哮喘是一种慢性炎症性疾病,对患者的健康具有严重影响。
方法:对来自日本东京都多摩市的10771名支气管哮喘患者进行为期5年的调查,对其哮喘治疗和生活质量(QOL)进行研究。入选患者年龄≥16岁,问卷调查由其主诊医生完成,研究时间为2002年11月至2006年。研究内容包括支气管哮喘症状、急诊就诊、药物使用和哮喘的严重程度。
结果:在为期5年的研究期内,哮喘症状得到了改善,急诊就诊次数下降。因为2002年有>80%的哮喘患者使用激素吸入(ICS)治疗,我们认为这些患者同时采用白三烯受体拮抗剂(LTRA)和长效β2受体激动剂(LABA)可能是导致上述结果的原因。因此,我们比较了ICS + LTRA (n = 45)和ICS + LABA (n = 54)治疗的疗效。两组之间在ICS使用剂量上无显著差异。在ICS + LABA 组,联合治疗前和联合治疗后,急诊就诊的患者比率分别为18.5%和22.2%,无显著差异。相反,在ICS + LTRA 组,患者在加用LTRA之后,急诊就诊患者比率从24.4%降低至6.6%。
结论:上述结果显示,除了ICS治疗的抗炎作用外,联合LTRA的抗炎作用,能降低支气管哮喘患者的急诊就诊频率。
(林江涛 审校)
Allergol Int. 2011 Jun 25. [Epub ahead of print]
Addition of Leukotriene Receptor Antagonists to Inhaled Corticosteroids Improved QOL of Patients with Bronchial Asthma Surveyed in Suburban Tokyo, Japan.
Ohshima N, Matsui H, Matsui Y, Kawashima M, Shimada M, Higaki N, Shoji S, Wada H, Fujita A, Watanabe H, Yamaguchi N, Matsuoka R, Oki K, Takahashi H, Suzuki M, Yamazaki H, Yoshizawa M, Goto H.
Source
Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Tokyo, Japan.
Abstract
BACKGROUND: Bronchial asthma is a chronic inflammatory disease that has a severe impact on health worldwide.
METHODS: A survey of 10,771 patients with bronchial asthma in the Tama region, Tokyo was conducted for 5 years to examine treatment and quality of life (QOL). Subjects were patients aged ≥16 years and their physicians who replied to a questionnaire sent in November from 2002 to 2006. Symptoms of bronchial asthma, visits to an emergency room, use of drugs, and severity of asthma were investigated.
RESULTS: Asthmatic symptoms improved over the 5 years, with a reduction in the number of emergency room visits. Since inhaled corticosteroids (ICS) were used by >80% of patients in 2002, we suspected that increased use of concomitant leukotriene receptor antagonists (LTRA) and long-acting β(2) agonists (LABA) might have contributed to these findings. The effects of these drugs were compared between ICS + LTRA (n = 45) and ICS + LABA (n = 54) groups of patients. There was no significant difference in the ICS dose between these groups. In the ICS + LABA group, 18.5% and 22.2% of patients visited an emergency room before and after initiation of combination therapy, respectively, with no statistically significant difference. In contrast, the rate of emergency room visits in the ICS + LTRA group decreased from 24.4% to 6.6% after addition of LTRA.
CONCLUSIONS: These results suggest that the frequency of visits to an emergency room was decreased by complementing the anti-inflammatory effect of ICS with further treatment of inflammation, particularly with LTRA
Allergol Int. 2011 Jun 25. [Epub ahead of print]
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法国青少年哮喘与严重抑郁发作的关系
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