家长启动的口服皮质激素治疗在学龄前儿童喘息和学龄期儿童哮喘治疗中的作用
2011/06/17
综述的目的:本文对家长启动的皮质激素口服(PIOCS)在治疗学龄前喘息和学龄期哮喘中的理论背景和当前证据进行综述。
近期结果:对于学龄期哮喘患儿,急性期给予PIOCS与哮喘症状和卫生资源利用轻度降低相关。对于学龄前喘息,OCS(包括PIOCS)可能是无效的。
总结:PIOCS对于学龄期急性哮喘疗效一般,对于学龄前喘息无效。对于年长的哮喘患儿,必须权衡PIOCS的潜在疗效和增加OCS使用所带来的副作用。
(苏楠 审校)
Curr Opin Allergy Clin Immunol. 2011 Apr 2. [Epub ahead of print]
The role of parent-initiated oral corticosteroids in preschool wheeze and school-aged asthma.
Vuillermin PJ, Robertson CF, South M.
aChild Health Research Unit, Barwon Health, Geelong, Australia bDepartment of Respiratory Medicine, Australia cDepartment of General Medicine, The Royal Children’s Hospital, Parkville, Victoria, Australia.
Abstract
PURPOSE OF REVIEW: To review the theoretical background and current evidence regarding parent-initiated oral corticosteroid (PIOCS) therapy in preschool wheeze and asthma in school-aged children.
RECENT FINDINGS: In school-aged children with asthma PIOCS, given during acute episodes, has been associated with a modest reduction in asthma symptoms and health resource utilisation. In preschool wheeze, OCS (including PIOCS) therapy appears to be ineffective.
SUMMARY: PIOCS is associated with modest benefits among school-aged children with acute asthma but is not effective among children with preschool wheeze. In older children with asthma, the potential benefits of PIOCS must be balanced against potential adverse effects associated with increased OCS administration.
Curr Opin Allergy Clin Immunol. 2011 Apr 2. [Epub ahead of print]
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