2个出生队列研究（ALSPAC和PIAMA）中儿童喘息表现型的比较
2011/05/11
摘要
背景：哮喘在儿童早期就可能出现，但儿童期不同的喘息表现形式，与之后出现的哮喘、过敏症和支气管高反应性(BHR)的关系也不一样。基于Avon儿童和家长的纵向研究(ALSPAC)数据，找到了新的喘息表现型。但目前尚不清楚其他的出生队列研究中是否也存在这些表现型。
目的：比较ALSPAC研究和哮喘与螨虫过敏的预防及发病率(PIAMA)研究中8岁内的喘息表现型。
方法：针对ALSPAC研究5760名儿童和PIAMA 研究2810名儿童，采用纵向潜在类别分析鉴别0～8岁间的喘息表现型。比较两个队列研究的表现性。采用加权回归分析评价这些表现型与哮喘、过敏症、BHR和肺功能的关系。
结果：8岁内PIAMA数据最佳拟合的模型为5个类别的模型。PIAMA研究的表现型与前期ALSPAC研究报道的类似，这也为2岁后出现的喘息表现型增加了证据。两个研究显示的表现型与哮喘、过敏症、BHR和肺功能的相关性也类似。
结论：纵向潜在类别分析鉴别的喘息表现型在两个出生队列研究中类似。不同表现型相关的遗传和环境因素研究将有助于阐明哮喘的起源。
（苏楠 审校）
J Allergy Clin Immunol. 2011 Mar 14. [Epub ahead of print]
Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA.
Savenije OE, Granell R, Caudri D, Koppelman GH, Smit HA, Wijga A, de Jongste JC, Brunekreef B, Sterne JA, Postma DS, Henderson J, Kerkhof M.
Department of Epidemiology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Abstract
BACKGROUND: Asthma has its origins in early childhood, but different patterns of childhood wheezing vary in their associations with subsequent asthma, atopy, and bronchial hyperresponsiveness (BHR). Novel wheezing phenotypes have been identified on the basis of analyses of longitudinal data from the Avon Longitudinal Study of Parents And Children (ALSPAC). It is unclear whether these phenotypes can be replicated in other birth cohorts.
OBJECTIVE: To compare wheezing phenotypes identified in the first 8 years of life in the ALSPAC study and the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) study.
METHODS: We used longitudinal latent class analysis to identify phenotypes on the basis of repeated reports of wheezing from 0 to 8 years in 5760 children from the ALSPAC study and 2810 children from the PIAMA study. Phenotypes were compared between cohorts. Associations with asthma, atopy, BHR, and lung function were analyzed by using weighted regression analyses.
RESULTS: The model with the best fit to PIAMA data in the first 8 years of life was a 5-class model. Phenotypes identified in the PIAMA study had wheezing patterns that were similar to those previously reported in ALSPAC, adding further evidence to the existence of an intermediate-onset phenotype with onset of wheeze after 2 years of age. Associations with asthma, atopy, BHR, and lung function were remarkably similar in the 2 cohorts.
CONCLUSION: Wheezing phenotypes identified by using longitudinal latent class analysis were comparable in 2 large birth cohorts. Study of genetic and environmental factors associated with different phenotypes may help elucidate the origins of asthma.
J Allergy Clin Immunol. 2011 Mar 14. [Epub ahead of print]
背景：哮喘在儿童早期就可能出现，但儿童期不同的喘息表现形式，与之后出现的哮喘、过敏症和支气管高反应性(BHR)的关系也不一样。基于Avon儿童和家长的纵向研究(ALSPAC)数据，找到了新的喘息表现型。但目前尚不清楚其他的出生队列研究中是否也存在这些表现型。
目的：比较ALSPAC研究和哮喘与螨虫过敏的预防及发病率(PIAMA)研究中8岁内的喘息表现型。
方法：针对ALSPAC研究5760名儿童和PIAMA 研究2810名儿童，采用纵向潜在类别分析鉴别0～8岁间的喘息表现型。比较两个队列研究的表现性。采用加权回归分析评价这些表现型与哮喘、过敏症、BHR和肺功能的关系。
结果：8岁内PIAMA数据最佳拟合的模型为5个类别的模型。PIAMA研究的表现型与前期ALSPAC研究报道的类似，这也为2岁后出现的喘息表现型增加了证据。两个研究显示的表现型与哮喘、过敏症、BHR和肺功能的相关性也类似。
结论：纵向潜在类别分析鉴别的喘息表现型在两个出生队列研究中类似。不同表现型相关的遗传和环境因素研究将有助于阐明哮喘的起源。
（苏楠 审校）
J Allergy Clin Immunol. 2011 Mar 14. [Epub ahead of print]
Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA.
Savenije OE, Granell R, Caudri D, Koppelman GH, Smit HA, Wijga A, de Jongste JC, Brunekreef B, Sterne JA, Postma DS, Henderson J, Kerkhof M.
Department of Epidemiology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Abstract
BACKGROUND: Asthma has its origins in early childhood, but different patterns of childhood wheezing vary in their associations with subsequent asthma, atopy, and bronchial hyperresponsiveness (BHR). Novel wheezing phenotypes have been identified on the basis of analyses of longitudinal data from the Avon Longitudinal Study of Parents And Children (ALSPAC). It is unclear whether these phenotypes can be replicated in other birth cohorts.
OBJECTIVE: To compare wheezing phenotypes identified in the first 8 years of life in the ALSPAC study and the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) study.
METHODS: We used longitudinal latent class analysis to identify phenotypes on the basis of repeated reports of wheezing from 0 to 8 years in 5760 children from the ALSPAC study and 2810 children from the PIAMA study. Phenotypes were compared between cohorts. Associations with asthma, atopy, BHR, and lung function were analyzed by using weighted regression analyses.
RESULTS: The model with the best fit to PIAMA data in the first 8 years of life was a 5-class model. Phenotypes identified in the PIAMA study had wheezing patterns that were similar to those previously reported in ALSPAC, adding further evidence to the existence of an intermediate-onset phenotype with onset of wheeze after 2 years of age. Associations with asthma, atopy, BHR, and lung function were remarkably similar in the 2 cohorts.
CONCLUSION: Wheezing phenotypes identified by using longitudinal latent class analysis were comparable in 2 large birth cohorts. Study of genetic and environmental factors associated with different phenotypes may help elucidate the origins of asthma.
J Allergy Clin Immunol. 2011 Mar 14. [Epub ahead of print]
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肥大细胞导致的气道结构改变参与了严重哮喘的致病过程
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饮食钠的控制和哮喘
