多症状哮喘与鼻塞、流涕和慢性鼻炎及鼻窦炎症状紧密相关---来自瑞典西部哮喘研究的证据
2011/03/24
摘要
背景：我们前期的研究显示，瑞典西部，约25%的哮喘患者出现多个哮喘症状，这些患者可以归为更为严重的疾病。此外，哮喘也与一些共患病相关，其中包括鼻炎、慢性鼻和鼻窦炎。本试验旨在研究多症状哮喘是否与严重哮喘的体征相关，以及多症状哮喘与过敏性慢性鼻炎、鼻窦炎不同症状之间的关系。
方法：本试验对2008年瑞典西部哮喘研究中哮喘患者的症状、鼻炎和慢性鼻炎和鼻窦炎进行研究，前述研究为采用OLIN和GA2LEN呼吸病和过敏症相关问卷调查进行的流行病学研究。
结果：在一般人群中，2.1%的人存在多个症状的哮喘。多症状哮喘患者其夜间因哮喘导致觉醒的风险为较少症状哮喘患者的2倍以上 (P < 0.001)。过敏性鼻炎在两组人群中的发病率相似，但鼻塞和流涕在多症状哮喘患者中更为常见（分别为OR 2.21; 95%CI 1.64-2.97和1.49; 1.10-2.02）。有任何1个或4个慢性鼻炎和鼻窦炎症状，能显著增加多症状哮喘的风险(P < 0.01)。
结论：流行病学研究发现的多症状哮喘患者，很大程度上具有严重哮喘的体征。鼻炎的严重程度（由鼻塞和流涕来表示）及出现任何或数个慢性鼻炎和鼻窦炎体征，都能显著增加多症状哮喘的风险。
（陈欣 审校）
Respir Res. 2010 Nov 26;11:163.
Multi-symptom asthma is closely related to nasal blockage, rhinorrhea and symptoms of chronic rhinosinusitis-evidence from the West Sweden Asthma Study.
Lötvall J, Ekerljung L, Lundbäck B.
Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Sweden. jan.lotvall@gu.se.
Abstract
BACKGROUND: We have previously shown that approximately 25% of those with asthma in West Sweden have multiple asthma symptoms, which may describe a group of patients with more severe disease. Furthermore, asthma is associated with several co-morbid diseases, including rhinitis and chronic rhinosinusitis. The aim of this study was to determine whether multi-symptom asthma is related to signs of severe asthma, and to investigate the association between multi-symptom asthma and different symptoms of allergic and chronic rhinosinusitis.
METHODS: This study analyzed data on asthma symptoms, rhinitis, and chronic rhinosinusitis from the 2008 West Sweden Asthma Study, which is an epidemiologically based study using the OLIN and GA2LEN respiratory and allergy focused questionnaires.
RESULTS: Multi-symptom asthma was present in 2.1% of the general population. Subjects with multi-symptom asthma had more than double the risk of having night-time awakenings caused by asthma compared with those with fewer asthma symptoms (P < 0.001). The prevalence of allergic rhinitis was similar in the fewer- and multi-symptom asthma groups, but nasal blockage and rhinorrhea were significantly increased in those with multi- versus fewer-symptom asthma (odds ratio 2.21; 95% confidence interval 1.64-2.97, versus 1.49; 1.10-2.02, respectively). Having any, or one to four symptoms of chronic rhinosinusitis significantly increased the risk of having multi- versus fewer-symptom asthma (P < 0.01).
CONCLUSION: An epidemiologically identified group of individuals with multiple asthma symptoms harbour to greater extent those with signs of severe asthma. The degree of rhinitis, described by the presence of symptoms of nasal blockage or rhinorrhea, as well as the presence of any or several signs of chronic rhinosinusitis, significantly increases the risk of having multi-symptom asthma.
Respir Res. 2010 Nov 26;11:163.
背景：我们前期的研究显示，瑞典西部，约25%的哮喘患者出现多个哮喘症状，这些患者可以归为更为严重的疾病。此外，哮喘也与一些共患病相关，其中包括鼻炎、慢性鼻和鼻窦炎。本试验旨在研究多症状哮喘是否与严重哮喘的体征相关，以及多症状哮喘与过敏性慢性鼻炎、鼻窦炎不同症状之间的关系。
方法：本试验对2008年瑞典西部哮喘研究中哮喘患者的症状、鼻炎和慢性鼻炎和鼻窦炎进行研究，前述研究为采用OLIN和GA2LEN呼吸病和过敏症相关问卷调查进行的流行病学研究。
结果：在一般人群中，2.1%的人存在多个症状的哮喘。多症状哮喘患者其夜间因哮喘导致觉醒的风险为较少症状哮喘患者的2倍以上 (P < 0.001)。过敏性鼻炎在两组人群中的发病率相似，但鼻塞和流涕在多症状哮喘患者中更为常见（分别为OR 2.21; 95%CI 1.64-2.97和1.49; 1.10-2.02）。有任何1个或4个慢性鼻炎和鼻窦炎症状，能显著增加多症状哮喘的风险(P < 0.01)。
结论：流行病学研究发现的多症状哮喘患者，很大程度上具有严重哮喘的体征。鼻炎的严重程度（由鼻塞和流涕来表示）及出现任何或数个慢性鼻炎和鼻窦炎体征，都能显著增加多症状哮喘的风险。
（陈欣 审校）
Respir Res. 2010 Nov 26;11:163.
Multi-symptom asthma is closely related to nasal blockage, rhinorrhea and symptoms of chronic rhinosinusitis-evidence from the West Sweden Asthma Study.
Lötvall J, Ekerljung L, Lundbäck B.
Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Sweden. jan.lotvall@gu.se.
Abstract
BACKGROUND: We have previously shown that approximately 25% of those with asthma in West Sweden have multiple asthma symptoms, which may describe a group of patients with more severe disease. Furthermore, asthma is associated with several co-morbid diseases, including rhinitis and chronic rhinosinusitis. The aim of this study was to determine whether multi-symptom asthma is related to signs of severe asthma, and to investigate the association between multi-symptom asthma and different symptoms of allergic and chronic rhinosinusitis.
METHODS: This study analyzed data on asthma symptoms, rhinitis, and chronic rhinosinusitis from the 2008 West Sweden Asthma Study, which is an epidemiologically based study using the OLIN and GA2LEN respiratory and allergy focused questionnaires.
RESULTS: Multi-symptom asthma was present in 2.1% of the general population. Subjects with multi-symptom asthma had more than double the risk of having night-time awakenings caused by asthma compared with those with fewer asthma symptoms (P < 0.001). The prevalence of allergic rhinitis was similar in the fewer- and multi-symptom asthma groups, but nasal blockage and rhinorrhea were significantly increased in those with multi- versus fewer-symptom asthma (odds ratio 2.21; 95% confidence interval 1.64-2.97, versus 1.49; 1.10-2.02, respectively). Having any, or one to four symptoms of chronic rhinosinusitis significantly increased the risk of having multi- versus fewer-symptom asthma (P < 0.01).
CONCLUSION: An epidemiologically identified group of individuals with multiple asthma symptoms harbour to greater extent those with signs of severe asthma. The degree of rhinitis, described by the presence of symptoms of nasal blockage or rhinorrhea, as well as the presence of any or several signs of chronic rhinosinusitis, significantly increases the risk of having multi-symptom asthma.
Respir Res. 2010 Nov 26;11:163.
上一篇：
年龄因素对儿童哮喘严重恶化风险和哮喘控制的影响
下一篇：
哮喘高危儿童中早期体重状态与哮喘的关系
