哮喘高危儿童中早期体重状态与哮喘的关系
2011/03/24
摘要
背景：已知肥胖是儿童哮喘的一大危险因素。
目的：本试验研究出生至5岁间的体重状态与6～8岁时哮喘发生的关系。
方法：285名足月、哮喘高风险新生儿（父母至少有一名患有哮喘或过敏症）入选此项童年开始的哮喘项目，研究时间从出生至8岁。超重定义为2岁前体重与身高比值的百分数大于85%和2～5岁时体重指数百分数大于85%。
结果：在各年龄儿童中，未观察到当前超重与喘息/哮喘的发生存在相关性。相反，纵向分析显示，曾经超重与哮喘存在复杂的关系。1岁时超重与6岁时（OR, 0.32; P =0.02）和8岁时(OR, 0.35; P = .04)的哮喘风险下降有关，而且这些儿童具有较好的肺功能。然而，婴儿期以外的超重未见于哮喘发生相关。实际上，仅那些5岁时超重的儿童（而非1岁时超重的儿童），在6岁时的哮喘风险增加（OR, 5.78; P =0.05）。
结论：对于遗传上哮喘高风险的儿童，1岁时超重与6岁和8岁时哮喘风险下降和较好的肺功能相关。然而，婴儿期以外的超重对哮喘并不产生保护作用，甚至能增加哮喘风险。
（陈欣 审校）
J Allergy Clin Immunol. 2010 Dec;126(6):1157-62. Epub 2010 Nov 4.
Early childhood weight status in relation to asthma development in high-risk children.
Zhang Z, Lai HJ, Roberg KA, Gangnon RE, Evans MD, Anderson EL, Pappas TE, Dasilva DF, Tisler CJ, Salazar LP, Gern JE, Lemanske RF Jr.
Department of Nutritional Sciences, University of Wisconsin College of Agriculture and Life Sciences, Madison, WI 53706-1562, USA. zhuminzhang@wisc.edu
Abstract
BACKGROUND: Obesity has been proposed to be a risk factor for the development of childhood asthma.
OBJECTIVE: We sought to examine weight status from birth to age 5 years in relation to the occurrence of asthma at ages 6 and 8 years.
METHODS: Two hundred eighty-five full-term high-risk newborns with at least 1 asthmatic/atopic parent enrolled in the Childhood Origin of Asthma project were studied from birth to age 8 years. Overweight was defined by weight-for-length percentiles of greater than the 85th percentile before the age of 2 years and a body mass index percentile of greater than the 85th percentile at ages 2 to 5 years.
RESULTS: No significant concurrent association was found between overweight status and wheezing/asthma occurrence at each year of age. In contrast, longitudinal analyses revealed complex relationships between being overweight and asthma. Being overweight at age 1 year was associated with a decreased risk of asthma at age 6 (odds ratio [OR], 0.32; P = .02) and 8 (OR, 0.35; P = .04) years, as well as better lung function. However, being overweight beyond infancy was not associated with asthma occurrence. In fact, only children who were overweight at age 5 years but not at age 1 year had an increased risk of asthma at age 6 years (OR, 5.78; P = .05).
CONCLUSION: In children genetically at high risk of asthma, being overweight at age 1 year was associated with a decreased risk of asthma and better lung function at ages 6 and 8 years. However, being overweight beyond infancy did not have any protective effect and even could confer a higher risk for asthma.
J Allergy Clin Immunol. 2010 Dec;126(6):1157-62. Epub 2010 Nov 4.
背景：已知肥胖是儿童哮喘的一大危险因素。
目的：本试验研究出生至5岁间的体重状态与6～8岁时哮喘发生的关系。
方法：285名足月、哮喘高风险新生儿（父母至少有一名患有哮喘或过敏症）入选此项童年开始的哮喘项目，研究时间从出生至8岁。超重定义为2岁前体重与身高比值的百分数大于85%和2～5岁时体重指数百分数大于85%。
结果：在各年龄儿童中，未观察到当前超重与喘息/哮喘的发生存在相关性。相反，纵向分析显示，曾经超重与哮喘存在复杂的关系。1岁时超重与6岁时（OR, 0.32; P =0.02）和8岁时(OR, 0.35; P = .04)的哮喘风险下降有关，而且这些儿童具有较好的肺功能。然而，婴儿期以外的超重未见于哮喘发生相关。实际上，仅那些5岁时超重的儿童（而非1岁时超重的儿童），在6岁时的哮喘风险增加（OR, 5.78; P =0.05）。
结论：对于遗传上哮喘高风险的儿童，1岁时超重与6岁和8岁时哮喘风险下降和较好的肺功能相关。然而，婴儿期以外的超重对哮喘并不产生保护作用，甚至能增加哮喘风险。
（陈欣 审校）
J Allergy Clin Immunol. 2010 Dec;126(6):1157-62. Epub 2010 Nov 4.
Early childhood weight status in relation to asthma development in high-risk children.
Zhang Z, Lai HJ, Roberg KA, Gangnon RE, Evans MD, Anderson EL, Pappas TE, Dasilva DF, Tisler CJ, Salazar LP, Gern JE, Lemanske RF Jr.
Department of Nutritional Sciences, University of Wisconsin College of Agriculture and Life Sciences, Madison, WI 53706-1562, USA. zhuminzhang@wisc.edu
Abstract
BACKGROUND: Obesity has been proposed to be a risk factor for the development of childhood asthma.
OBJECTIVE: We sought to examine weight status from birth to age 5 years in relation to the occurrence of asthma at ages 6 and 8 years.
METHODS: Two hundred eighty-five full-term high-risk newborns with at least 1 asthmatic/atopic parent enrolled in the Childhood Origin of Asthma project were studied from birth to age 8 years. Overweight was defined by weight-for-length percentiles of greater than the 85th percentile before the age of 2 years and a body mass index percentile of greater than the 85th percentile at ages 2 to 5 years.
RESULTS: No significant concurrent association was found between overweight status and wheezing/asthma occurrence at each year of age. In contrast, longitudinal analyses revealed complex relationships between being overweight and asthma. Being overweight at age 1 year was associated with a decreased risk of asthma at age 6 (odds ratio [OR], 0.32; P = .02) and 8 (OR, 0.35; P = .04) years, as well as better lung function. However, being overweight beyond infancy was not associated with asthma occurrence. In fact, only children who were overweight at age 5 years but not at age 1 year had an increased risk of asthma at age 6 years (OR, 5.78; P = .05).
CONCLUSION: In children genetically at high risk of asthma, being overweight at age 1 year was associated with a decreased risk of asthma and better lung function at ages 6 and 8 years. However, being overweight beyond infancy did not have any protective effect and even could confer a higher risk for asthma.
J Allergy Clin Immunol. 2010 Dec;126(6):1157-62. Epub 2010 Nov 4.
上一篇：
多症状哮喘与鼻塞、流涕和慢性鼻炎及鼻窦炎症状紧密相关---来自瑞典西部哮喘研究的证据
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采用哮喘控制问卷调查来预测哮喘加重风险
