针灸作为成人哮喘的辅助治疗：初步随机研究
2011/01/27
摘要
目的：本试验旨在采用传统方案治疗的哮喘患者中评价针灸的疗效。
参与者与方法：本试验为前瞻性、随机、患者/评价者双盲、对照研究。经过一周的磨合期后，45名入选患者随机分为3组：针灸组、假针灸组及等待治疗组。所有患者仍继续采用其他已经使用的哮喘治疗方法。针灸组和假针灸组，患者接受每周3次针刺，连续4周，随后随访2周。主要结果包括检测呼气峰值流量（PEF），次要检测结果包括第一秒用力呼气体积（FEV1）、采用韩国成人哮喘患者生活质量问卷表检测生活质量（QLQAKA）、短暂呼吸困难指数（TDI）、血清嗜酸性粒细胞技术、总血清免疫球蛋白E（IgE）。
结果：每周平均PEF（早晨记录）和FEV1在组间和组内不存在显著差异。随机分组后2、4和6周，针灸组与等待治疗组相比，QLQAKA和TDI显著改善。
讨论：对于采用传统哮喘治疗的患者，针灸作为一个辅助治疗，并不能改善哮喘患者肺功能。然而，4周内12次的针灸治疗对成人哮喘患者的生活质量有所改善。有必要进行大样本量的试验，研究针灸在改善哮喘患者症状和生活质量上的有效性。
（苏楠 审校）
J Asthma. 2010 Aug 11. [Epub ahead of print]
A Randomized Pilot Study of Acupuncture as an Adjunct Therapy in Adult Asthmatic Patients.
Choi JY, Jung HJ, Kim JI, Lee MS, Kang KW, Roh YL, Choi SM, Jung SK.
Acupuncture, Moxibustion & Meridian Research Center, Division of Standard Research, Korea Institute of Oriental Medicine, Republic of Korea.
Abstract
Objective. This trial aimed to evaluate the feasibility of estimating the effectiveness of acupuncture on asthmatic patients under conventional medical management.
Participations and Methods. A prospective randomized, patient/assessor-blinded, sham acupuncture-, and waiting list-controlled pilot trial was conducted. Forty-five eligible asthmatic participants underwent a 1-week run-in period and were then randomized into one of three groups: an active acupuncture group, a sham acupuncture group, and a waiting list group. They were instructed to maintain the use of antiasthmatic medications. Needling was administered three times per week for 4 weeks with a 2-week follow-up in the active and sham acupuncture groups. The primary outcome was daily morning peak expiratory flow (PEF) and the secondary outcomes included forced expiratory volume one second (FEV(1)), quality of life questionnaire for adult Korean asthmatics (QLQAKA), transition dyspnea index (TDI), serum eosinophil count, and total serum immunoglobulin E (IgE).
Results. No significant differences in the between- or within-group values of weekly average PEF (recorded daily in the morning) and FEV(1) were found. For QLQAKA and TDI, the active acupuncture group showed a significant improvement over the waiting list group at 2, 4, and 6 weeks after randomization.
Discussion. Acupuncture as an adjunct therapy to conventional medical care does not seem to affect pulmonary function in asthmatic patients. However, 12 sessions of acupuncture treatment during 4 weeks showed a favorable effect on the quality of life in adult asthmatic patients. Further large trials assessing the effectiveness of acupuncture on the quality of life and symptoms in asthmatic patients are needed.
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与普通急诊相比，儿科急诊更可能采用全身皮质激素治疗哮喘恶化
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成人哮喘患者每年呼吸功能的变化：多年哮喘治疗在修复气道不可逆性变化中的作用
