鼻窦支气管综合征患者中COX-2在辣椒素诱导的咳嗽反应敏感性中的作用
2011/01/27
摘要
背景：鼻窦支气管综合征是慢性湿性咳嗽的一个病因。炎症介质参与了慢性湿性咳嗽。越来越多的证据表明，环氧化酶（COX）2（COX的诱导亚型之一）是诸多炎症性疾病的病理生理过程的关键成员。鼻窦支气管综合征表现为支气管中性粒细胞性炎症。然而，这些患者中，目前对COX-2在慢性生痰性咳嗽中的作用了解较少。
方法：本试验为随机、安慰剂对照、交叉研究。15名鼻窦支气管综合征患者入选，研究依托度酸（COX-2抑制剂）对辣椒素吸入诱发咳嗽反应的影响。辣椒素吸入诱发咳嗽的阈值定义为导致5次或5次以上咳嗽的辣椒素的浓度，将其作为气道咳嗽反射敏感性的一个指标。
结果：采用依托度酸治疗2周后（200 mg，每天2次，口服），与安慰剂组相比，咳嗽阈值显著增加（37.5 (GSEM 1.3) vs. 27.2 (GSEM 1.3) muM；P< 0.03）。
结论：COX-2可能为一个调节因子，能增加鼻窦支气管综合征患者气道咳嗽反射敏感性。
（林教授 审校）
Cough. 2010 Aug 9;6:7
Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome.
Ishiura Y, Fujimura M, Yamamoto H, Ohkura N, Myou S.
The Department of Internal Medicine, Toyama City Hospital, Toyama, Japan. ishiura-@p2322.nsk.ne.jp.
Abstract
BACKGROUND: Sinobronchial syndrome is a cause of chronic productive cough. Inflammatory mediators are involved in the pathophysiology of chronic productive cough. Accumulating evidences indicate that cyclooxygenase (COX)-2, one of the inducible isoforms of COX, is a key element in the pathophysiological process of a number of inflammatory disorders. However, little is known about the role of COX-2 in chronic productive cough in patients with sinobronchial syndrome known as neutrophilic bronchial inflammation.
METHODS: The effect of etodolac, a potent COX-2 inhibitor, on cough response to inhaled capsaicin was examined in 15 patients with sinobronchial syndrome in a randomized, placebo-controlled cross-over study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity.
RESULTS: The cough threshold was significantly (p < 0.03) increased after two-week treatment with etodolac (200 mg twice a day orally) compared with placebo [37.5 (GSEM 1.3) vs. 27.2 (GSEM 1.3) muM].
CONCLUSIONS: These findings indicate that COX-2 may be a possible modulator augmenting airway cough reflex sensitivity in patients with sinobronchial syndrome
上一篇：
德国呼吸学会关于成人急性和慢性咳嗽诊断和治疗指南
下一篇：
ERS标准柠檬酸咳嗽激发试验在健康成人志愿者中的有效性
