咳嗽评价的有效方法：系统性文献综述
2010/12/31
摘要
背景：咳嗽是一种常见症状，患者常常因此寻求医疗帮助，而耗费大量药物。对于医生和临床研究者来说，评价咳嗽的临床重要性及其对治疗的反应都是一项挑战。
目的：本项系统性综述有以下目的：首先，总结目前评价咳嗽的有效工具；第二，研究不同评价方法所产生结果的相关性程度；
方法：两名独立研究者查询Medline, Embase和Cochrane数据库，选取评价咳嗽评价工具的研究。
结果：共有34项研究入选。一些非卧床咳嗽检测仪能够自动鉴别咳嗽，在有限的患者群中显示有效。3个咳嗽特异性生命质量量表（莱斯特问卷调查、咳嗽生命质量问卷调查和咳嗽负担问卷调查）被证实有效。未发现有关描述性评分和视觉模拟评分有效性的研究。生活质量评分与咳嗽频率具有较好的相关性。描述性评分和视觉模拟评分与其它客观评价方法（如：咳嗽频率监测或生活质量评分）的相关性不一致。
结论：咳嗽特异性生命质量问卷调查能为咳嗽研究提供有效结果。虽然当前咳嗽检测工具的开发很有希望，但是，在被作为推荐方法广泛使用之前，还需进行更多研究，需包括更大样本量、基于更为实际的环境、并且针对不同的咳嗽形式。
（林江涛 审校）
Respiration. 2010 Nov 13. [Epub ahead of print]
Validated Methods of Cough Assessment: A Systematic Review of the Literature.
Leconte S, Ferrant D, Dory V, Degryse J.
Institut de Recherche Santé et Société, Centre Académique de Médecine Générale, Université catholique de Louvain, Bruxelles, Belgique.
Abstract
Background: Cough is a common symptom for which patients often seek medical advice and consume vast amounts of drugs. It is a real challenge for both the physician and the clinical researcher to evaluate a cough’s clinical importance and its precise response to treatment. Objectives: This systematic literature review has the following objectives: first, to make an inventory of the validated tools for assessing cough, and second, to investigate the extent to which the results of various assessment methods can be correlated. Methods: Two independent investigators searched the Medline, Embase, and Cochrane databases for validation studies on cough assessment tools. Results: Thirty-four studies were included. Several ambulatory cough monitors automatically identify cough and have been validated in a limited number of patients. Three cough-specific quality-of-life scales (Leicester Cough Questionnaire, Cough Quality of Life Questionnaire, and Burden of Cough Questionnaire) have been validated. No validation studies of descriptive scores or visual analogue scales were found. The correlations between quality-of-life scores and cough frequency were good. The correlations between descriptive scores or visual analogue scales and more objective methods, such as cough frequency monitoring or quality-of-life scores, were inconsistent. Conclusion: Cough-specific quality-of-life questionnaires can provide valid outcomes for research into cough. Although the current developments in cough monitoring devices are promising, further studies on a larger scale, under more realistic conditions, and for different patterns of cough are required before they can be recommended for widespread use.
Respiration. 2010 Nov 13. [Epub ahead of print]
背景：咳嗽是一种常见症状，患者常常因此寻求医疗帮助，而耗费大量药物。对于医生和临床研究者来说，评价咳嗽的临床重要性及其对治疗的反应都是一项挑战。
目的：本项系统性综述有以下目的：首先，总结目前评价咳嗽的有效工具；第二，研究不同评价方法所产生结果的相关性程度；
方法：两名独立研究者查询Medline, Embase和Cochrane数据库，选取评价咳嗽评价工具的研究。
结果：共有34项研究入选。一些非卧床咳嗽检测仪能够自动鉴别咳嗽，在有限的患者群中显示有效。3个咳嗽特异性生命质量量表（莱斯特问卷调查、咳嗽生命质量问卷调查和咳嗽负担问卷调查）被证实有效。未发现有关描述性评分和视觉模拟评分有效性的研究。生活质量评分与咳嗽频率具有较好的相关性。描述性评分和视觉模拟评分与其它客观评价方法（如：咳嗽频率监测或生活质量评分）的相关性不一致。
结论：咳嗽特异性生命质量问卷调查能为咳嗽研究提供有效结果。虽然当前咳嗽检测工具的开发很有希望，但是，在被作为推荐方法广泛使用之前，还需进行更多研究，需包括更大样本量、基于更为实际的环境、并且针对不同的咳嗽形式。
（林江涛 审校）
Respiration. 2010 Nov 13. [Epub ahead of print]
Validated Methods of Cough Assessment: A Systematic Review of the Literature.
Leconte S, Ferrant D, Dory V, Degryse J.
Institut de Recherche Santé et Société, Centre Académique de Médecine Générale, Université catholique de Louvain, Bruxelles, Belgique.
Abstract
Background: Cough is a common symptom for which patients often seek medical advice and consume vast amounts of drugs. It is a real challenge for both the physician and the clinical researcher to evaluate a cough’s clinical importance and its precise response to treatment. Objectives: This systematic literature review has the following objectives: first, to make an inventory of the validated tools for assessing cough, and second, to investigate the extent to which the results of various assessment methods can be correlated. Methods: Two independent investigators searched the Medline, Embase, and Cochrane databases for validation studies on cough assessment tools. Results: Thirty-four studies were included. Several ambulatory cough monitors automatically identify cough and have been validated in a limited number of patients. Three cough-specific quality-of-life scales (Leicester Cough Questionnaire, Cough Quality of Life Questionnaire, and Burden of Cough Questionnaire) have been validated. No validation studies of descriptive scores or visual analogue scales were found. The correlations between quality-of-life scores and cough frequency were good. The correlations between descriptive scores or visual analogue scales and more objective methods, such as cough frequency monitoring or quality-of-life scores, were inconsistent. Conclusion: Cough-specific quality-of-life questionnaires can provide valid outcomes for research into cough. Although the current developments in cough monitoring devices are promising, further studies on a larger scale, under more realistic conditions, and for different patterns of cough are required before they can be recommended for widespread use.
Respiration. 2010 Nov 13. [Epub ahead of print]
上一篇：
初级医疗机构患有急性咳嗽的成人患者中进行CRP检测和临床表现对开具抗生素处方的影响
下一篇：
随机临床试验：大剂量胃酸抑制剂治疗慢性咳嗽——一项双盲、安慰剂对照研究
