哮喘控制检测的有效性和可靠性证据：来自希腊的研究
2010/12/31
摘要
背景：已有2个结论相反的研究探讨了哮喘控制检测（ACT）的维度。至今，ACT尚未在希腊人群中得到证实。
目的：本试验旨在检测处于专科医生治疗状态的希腊哮喘患者中，ACT反应的有效性和可靠性。
研究设计：基于样本特异性的有效性证据，通过构建、横断面、聚合效度、区分效度、內部一致性、再测信度、近似值均方根误差(RMSEA)，检测ACT(n = 100) 。
结果：单因素解决方案符合相关数据[χ2= 3.899, df (自由度) 5, ns, RMSEA <0.001]。对于所有样本，ACT具有较高的內部一致性（克朗巴赫系数= 0.72）和较高的2个月再测信度(IR = 0.85)。基于专家分级，哮喘控制患者的5个分类（基本未控制、控制较差、某种程度控制、较好控制、完全控制）之间在ACT上存在显著差异性(p <0.001)。哮喘控制和未控制患者之间(p =0.001)、不同性别人群之间(p =0.05)、不同教育程度人群之间(p =0.05)、不同平均年收入人群之间(p =0.01)、不同体重指数之间(p =0.05)、不同随访次数(p =0.01)及不同年龄(p <0.001)和不同严重程度(p <0.001)患者之间，存在显著差异。在筛查非控制哮喘时，ACT评分≤19能在敏感性(98.46)和特异性(88.57)之间提供最佳平衡。横断面有效性检测显示，ACT评分与FEV1预测值(r = 0.57, p <0.001)和残疾(r = -0.42, p <0.001)呈现中度相关，而与呼吸困难高度相关(r = -0.71, p <0.001)。聚合效度检测显示，ACT评分与专家分级相关(r = 0.89, p <0.001)。
结论：对于处于专科医生治疗状态的希腊哮喘门诊患者，ACT是有效且可靠的。
（刘国梁 审校）
J Asthma. 2010 Nov 1. [Epub ahead of print]
Validity and Reliability Evidence of the Asthma Control Test - Act in Greece.
Grammatopoulou EP, Stavrou N, Myrianthefs P, Karteroliotis K, Baltopoulos G, Behrakis P, Koutsouki D.
Department of Physical Education and Sport Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Abstract
Background. The dimensionality of the Asthma Control Test (ACT) was examined in two counterview studies. Up to now, the ACT has not been validated for the Greek asthma patients. Objective. The present study was designed to examine the validity and reliability of the ACT responses in Greek asthma outpatients under a specialist’s care. Study design. Following evidence for sample-specific validity, the ACT (n = 100) was examined through construct, cross-sectional, convergent, and discriminant validity as well as internal consistency and test-retest reliability [root mean squared error of approximation (RMSEA)]. Results. A one-factor solution fit the data [χ(2) (chi-square) = 3.899, df (degrees of freedom) 5, ns, RMSEA <0.001]. The ACT showed a high internal consistency (Cronbach alpha = 0.72) and a high 2 months test-retest reliability (IR = 0.85) for the total sample. Significant differences were found between the five categories of asthma control patients (not controlled at all, poorly controlled, somewhat controlled, well controlled, and completely controlled), according to the specialists’ rating, for the ACT (p < .001). Significant differences were found between patients with and without asthma control (p = .001), patients of different gender (p = .05), educational status (p = .05), mean year income (p = .01), body mass index (p = .05), follow-up visits (p = .01), as well as among patients of different age (p < .001) and severity (p < .001). An ACT score of 19 or less provided optimum balance of sensitivity (98.46) and specificity (88.57) for screening ’not controlled’ asthma. Cross-sectional validity testing showed moderate correlation of the ACT score with FEV1% predicted (r = 0.57, p < .001) and disability (r = -0.42, p < .001) and moderately high correlation with dyspnea (r = -0.71, p < .001). Convergent validity testing showed that the ACT score was correlated with the specialists’ rating (r = 0.89, p < .001). Conclusion. The ACT is valid and reliable in Greek outpatients with asthma under a specialist’s care.
J Asthma. 2010 Nov 1. [Epub ahead of print]
背景：已有2个结论相反的研究探讨了哮喘控制检测（ACT）的维度。至今，ACT尚未在希腊人群中得到证实。
目的：本试验旨在检测处于专科医生治疗状态的希腊哮喘患者中，ACT反应的有效性和可靠性。
研究设计：基于样本特异性的有效性证据，通过构建、横断面、聚合效度、区分效度、內部一致性、再测信度、近似值均方根误差(RMSEA)，检测ACT(n = 100) 。
结果：单因素解决方案符合相关数据[χ2= 3.899, df (自由度) 5, ns, RMSEA <0.001]。对于所有样本，ACT具有较高的內部一致性（克朗巴赫系数= 0.72）和较高的2个月再测信度(IR = 0.85)。基于专家分级，哮喘控制患者的5个分类（基本未控制、控制较差、某种程度控制、较好控制、完全控制）之间在ACT上存在显著差异性(p <0.001)。哮喘控制和未控制患者之间(p =0.001)、不同性别人群之间(p =0.05)、不同教育程度人群之间(p =0.05)、不同平均年收入人群之间(p =0.01)、不同体重指数之间(p =0.05)、不同随访次数(p =0.01)及不同年龄(p <0.001)和不同严重程度(p <0.001)患者之间，存在显著差异。在筛查非控制哮喘时，ACT评分≤19能在敏感性(98.46)和特异性(88.57)之间提供最佳平衡。横断面有效性检测显示，ACT评分与FEV1预测值(r = 0.57, p <0.001)和残疾(r = -0.42, p <0.001)呈现中度相关，而与呼吸困难高度相关(r = -0.71, p <0.001)。聚合效度检测显示，ACT评分与专家分级相关(r = 0.89, p <0.001)。
结论：对于处于专科医生治疗状态的希腊哮喘门诊患者，ACT是有效且可靠的。
（刘国梁 审校）
J Asthma. 2010 Nov 1. [Epub ahead of print]
Validity and Reliability Evidence of the Asthma Control Test - Act in Greece.
Grammatopoulou EP, Stavrou N, Myrianthefs P, Karteroliotis K, Baltopoulos G, Behrakis P, Koutsouki D.
Department of Physical Education and Sport Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Abstract
Background. The dimensionality of the Asthma Control Test (ACT) was examined in two counterview studies. Up to now, the ACT has not been validated for the Greek asthma patients. Objective. The present study was designed to examine the validity and reliability of the ACT responses in Greek asthma outpatients under a specialist’s care. Study design. Following evidence for sample-specific validity, the ACT (n = 100) was examined through construct, cross-sectional, convergent, and discriminant validity as well as internal consistency and test-retest reliability [root mean squared error of approximation (RMSEA)]. Results. A one-factor solution fit the data [χ(2) (chi-square) = 3.899, df (degrees of freedom) 5, ns, RMSEA <0.001]. The ACT showed a high internal consistency (Cronbach alpha = 0.72) and a high 2 months test-retest reliability (IR = 0.85) for the total sample. Significant differences were found between the five categories of asthma control patients (not controlled at all, poorly controlled, somewhat controlled, well controlled, and completely controlled), according to the specialists’ rating, for the ACT (p < .001). Significant differences were found between patients with and without asthma control (p = .001), patients of different gender (p = .05), educational status (p = .05), mean year income (p = .01), body mass index (p = .05), follow-up visits (p = .01), as well as among patients of different age (p < .001) and severity (p < .001). An ACT score of 19 or less provided optimum balance of sensitivity (98.46) and specificity (88.57) for screening ’not controlled’ asthma. Cross-sectional validity testing showed moderate correlation of the ACT score with FEV1% predicted (r = 0.57, p < .001) and disability (r = -0.42, p < .001) and moderately high correlation with dyspnea (r = -0.71, p < .001). Convergent validity testing showed that the ACT score was correlated with the specialists’ rating (r = 0.89, p < .001). Conclusion. The ACT is valid and reliable in Greek outpatients with asthma under a specialist’s care.
J Asthma. 2010 Nov 1. [Epub ahead of print]
上一篇：
哮喘患者的高血清精氨酸酶I水平：与高敏感性C反应蛋白的相关性
下一篇：
依从性干预项目对哮喘患者的用药依从性障碍、哮喘控制和日常活动/能力的影响
