过敏性鼻炎和/或哮喘患儿呼出气一氧化氮：与支气管高反应性的关系
2010/12/17
摘要
背景：当前，门诊检测呼出气一氧化氮分数(FeNO)可用于评价气道炎症，而且对于FeNO的检测，国际上存在共识。本研究旨在评价检测FeNO是否可用于评价过敏性鼻炎和/或哮喘患儿支气管高反应性(BHR)。
方法：280名过敏性鼻炎和/或过敏性哮喘患儿入选本研究。评价这些患儿的支气管功能（FEV1和FEF25-75）、BHR（乙酰甲胆碱激发试验评估）、FeNO和致敏性。
结果：支气管功能、BHR和FeNO在三组儿童中存在显著差异(P<0 .001)。哮喘及哮喘合并鼻炎患儿中，FeNO与BHR存在明显的负相关（分别为r = -0.63和r = -0.61）。FeNO截点为32 ppb时是BHR的一个预测因子。
结论：FeNO是过敏症儿童BHR的一个可能标志物，而且显示，这些儿童上下气道病变存在显著相关性。
（林江涛 审校）
J Asthma.2010 Oct 15. [Epub ahead of print]
Exhaled nitric oxide in children with allergic rhinitis and/or asthma: a relationship with bronchial hyperreactivity.
Ciprandi G, Tosca MA, Capasso M.
Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino-University of Genoa, Genoa, Italy.
Abstract
Background. Nowadays, the measure of the fractional concentration of exhaled nitric oxide (FeNO) enables to assess airway inflammation during an office visit and there is international consensus on this testing methodology. The aim of this study was to evaluate whether FeNO measurement is predictable for bronchial hyperreactivity (BHR) in children with allergic rhinitis, asthma, or both. Methods. Two hundred and eighty children with allergic rhinitis, allergic asthma, or both were evaluated. Bronchial function (FEV(1) and FEF(25-75)), BHR (assessed by methacholine challenge), FeNO, and sensitizations were assessed. Results. Bronchial function, BHR, and FeNO were significantly different in the three groups (p < .001). A strong inverse correlation between FeNO and BHR was found in patients with asthma and with asthma and rhinitis (r = -0.63 and r = -0.61, respectively). A cutoff of 32 ppb of FeNO was a predictive factor for BHR. Conclusions. This study highlights the relevance of FeNO as possible marker for BHR in allergic children and underlines the close link between upper and lower airways.
J Asthma. 2010 Oct 15. [Epub ahead of print]
背景：当前，门诊检测呼出气一氧化氮分数(FeNO)可用于评价气道炎症，而且对于FeNO的检测，国际上存在共识。本研究旨在评价检测FeNO是否可用于评价过敏性鼻炎和/或哮喘患儿支气管高反应性(BHR)。
方法：280名过敏性鼻炎和/或过敏性哮喘患儿入选本研究。评价这些患儿的支气管功能（FEV1和FEF25-75）、BHR（乙酰甲胆碱激发试验评估）、FeNO和致敏性。
结果：支气管功能、BHR和FeNO在三组儿童中存在显著差异(P<0 .001)。哮喘及哮喘合并鼻炎患儿中，FeNO与BHR存在明显的负相关（分别为r = -0.63和r = -0.61）。FeNO截点为32 ppb时是BHR的一个预测因子。
结论：FeNO是过敏症儿童BHR的一个可能标志物，而且显示，这些儿童上下气道病变存在显著相关性。
（林江涛 审校）
J Asthma.2010 Oct 15. [Epub ahead of print]
Exhaled nitric oxide in children with allergic rhinitis and/or asthma: a relationship with bronchial hyperreactivity.
Ciprandi G, Tosca MA, Capasso M.
Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino-University of Genoa, Genoa, Italy.
Abstract
Background. Nowadays, the measure of the fractional concentration of exhaled nitric oxide (FeNO) enables to assess airway inflammation during an office visit and there is international consensus on this testing methodology. The aim of this study was to evaluate whether FeNO measurement is predictable for bronchial hyperreactivity (BHR) in children with allergic rhinitis, asthma, or both. Methods. Two hundred and eighty children with allergic rhinitis, allergic asthma, or both were evaluated. Bronchial function (FEV(1) and FEF(25-75)), BHR (assessed by methacholine challenge), FeNO, and sensitizations were assessed. Results. Bronchial function, BHR, and FeNO were significantly different in the three groups (p < .001). A strong inverse correlation between FeNO and BHR was found in patients with asthma and with asthma and rhinitis (r = -0.63 and r = -0.61, respectively). A cutoff of 32 ppb of FeNO was a predictive factor for BHR. Conclusions. This study highlights the relevance of FeNO as possible marker for BHR in allergic children and underlines the close link between upper and lower airways.
J Asthma. 2010 Oct 15. [Epub ahead of print]
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月经前哮喘和症状与月经前综合征有关
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重度难治性哮喘的呼出气一氧化氮与呼出气冷凝液pH值
