蜂蜜、右美沙芬和苯海拉明对儿童夜间咳嗽及儿童和父母睡眠质量的影响
2010/09/14
摘要
目的：咳嗽是上呼吸道感染(URIs)的常见症状，常可导致儿童及其父母睡眠障碍。目前，尚未有可靠的治疗方法来控制URIs及其相关咳嗽。目前常用的药物有右美沙芬（DM）、苯海拉明（DPH）。本试验旨在比较蜂蜜、DM和DPH对儿童咳嗽及儿童和其父母睡眠质量的影响。
设计：本项临床试验有139名年龄为24～60个月的儿童参与，这些儿童因上呼吸道感染而出现咳嗽症状，随机分为4组。第一组采用蜂蜜治疗（HG），第二组采用DM治疗（DMG），第三组采用DPH治疗（DPHG），第四组采用支持治疗(CG)，作为对照组。
结果监测：患儿治疗24 h后，再次对其进行检查。采用含有李克特式问题的问卷调查检测咳嗽频率、咳嗽严重程度、儿童和其父母睡眠治疗。
结果：HG组咳嗽频率评分在治疗前后分别为4.09±0.72和1.93±0.65，而在CG组分别为4.11±0.78和3.11±0.57。治疗后各变量的平均评分存在统计学差异。HG组所有变量的平均评分显著高于其他组。虽然DMG组与DPHG组未见显著差异，但DMG组和CG组间存在显著相关性。
结论：与DM和DPH治疗相比，睡前服用2.5 ml蜂蜜能显著改善因上呼吸道感染而诱发的咳嗽。
（林江涛 审校）
J Altern Complement Med. 2010 Jul 12. [Epub ahead of print]
The Comparison of the Effect of Honey, Dextromethorphan, and Diphenhydramine on the Nightly Cough and Sleep Quality of Children and Their Parents
Shadkam MN, Mozaffari-Khosravi H, Mozayan MR.
1 Department of Pediatrics, Shahid Sadoughi University of Medical Sciences , Yazd, Iran .
Abstract
Objectives: Coughing is a prevalent symptom of upper respiratory infections (URIs) that cause disturbance in the sleep of children and their parents. There is as yet no reliable treatment to control URIs and their related cough; however, drugs such as dextromethorphan (DM) and diphenhydramine (DPH) are now mainly used in the world. The aim of this study is to compare the effect of honey, DM, and DPH on the nightly cough and sleep quality of children and their parents.
Design: This was a clinical trial study in which 139 children aged 24-60 months suffering from coughing due to URIs were selected and assigned randomly to 4 groups. The first group received honey (HG), the second one DM (DMG), the third DPH (DPHG), but the fourth group or control group (CG) was assigned to a supportive treatment. Outcome measures: After approximately a 24-hour intervention, the 4 groups were reexamined and their cough frequency, cough severity, and sleep quality in children and their parents were recorded by using the questionnaire with Likert-type questions.
Results: The mean of cough frequency score HG is 4.09 +/- 0.72 and 1.93 +/- 0.65 before and after the intervention, respectively, while these figures for the CG are 4.11 +/- 0.78 and 3.11 +/- 0.57, respectively. After the intervention, the difference of the mean score of the variables in all groups became statistically significant. The mean score of all variables in HG has stood significantly higher than those in other groups. There is also a significant relationship between the DMG and CG groups, even though there is no statistically difference between DMG and DPHG groups.
Conclusions: The result of the study demonstrated that receiving a 2.5-mL dose of honey before sleep has a more alleviating effect on URIs-induced cough compared with DM and DPH doses.
J Altern Complement Med. 2010 Jul 12. [Epub ahead of print]
目的：咳嗽是上呼吸道感染(URIs)的常见症状，常可导致儿童及其父母睡眠障碍。目前，尚未有可靠的治疗方法来控制URIs及其相关咳嗽。目前常用的药物有右美沙芬（DM）、苯海拉明（DPH）。本试验旨在比较蜂蜜、DM和DPH对儿童咳嗽及儿童和其父母睡眠质量的影响。
设计：本项临床试验有139名年龄为24～60个月的儿童参与，这些儿童因上呼吸道感染而出现咳嗽症状，随机分为4组。第一组采用蜂蜜治疗（HG），第二组采用DM治疗（DMG），第三组采用DPH治疗（DPHG），第四组采用支持治疗(CG)，作为对照组。
结果监测：患儿治疗24 h后，再次对其进行检查。采用含有李克特式问题的问卷调查检测咳嗽频率、咳嗽严重程度、儿童和其父母睡眠治疗。
结果：HG组咳嗽频率评分在治疗前后分别为4.09±0.72和1.93±0.65，而在CG组分别为4.11±0.78和3.11±0.57。治疗后各变量的平均评分存在统计学差异。HG组所有变量的平均评分显著高于其他组。虽然DMG组与DPHG组未见显著差异，但DMG组和CG组间存在显著相关性。
结论：与DM和DPH治疗相比，睡前服用2.5 ml蜂蜜能显著改善因上呼吸道感染而诱发的咳嗽。
（林江涛 审校）
J Altern Complement Med. 2010 Jul 12. [Epub ahead of print]
The Comparison of the Effect of Honey, Dextromethorphan, and Diphenhydramine on the Nightly Cough and Sleep Quality of Children and Their Parents
Shadkam MN, Mozaffari-Khosravi H, Mozayan MR.
1 Department of Pediatrics, Shahid Sadoughi University of Medical Sciences , Yazd, Iran .
Abstract
Objectives: Coughing is a prevalent symptom of upper respiratory infections (URIs) that cause disturbance in the sleep of children and their parents. There is as yet no reliable treatment to control URIs and their related cough; however, drugs such as dextromethorphan (DM) and diphenhydramine (DPH) are now mainly used in the world. The aim of this study is to compare the effect of honey, DM, and DPH on the nightly cough and sleep quality of children and their parents.
Design: This was a clinical trial study in which 139 children aged 24-60 months suffering from coughing due to URIs were selected and assigned randomly to 4 groups. The first group received honey (HG), the second one DM (DMG), the third DPH (DPHG), but the fourth group or control group (CG) was assigned to a supportive treatment. Outcome measures: After approximately a 24-hour intervention, the 4 groups were reexamined and their cough frequency, cough severity, and sleep quality in children and their parents were recorded by using the questionnaire with Likert-type questions.
Results: The mean of cough frequency score HG is 4.09 +/- 0.72 and 1.93 +/- 0.65 before and after the intervention, respectively, while these figures for the CG are 4.11 +/- 0.78 and 3.11 +/- 0.57, respectively. After the intervention, the difference of the mean score of the variables in all groups became statistically significant. The mean score of all variables in HG has stood significantly higher than those in other groups. There is also a significant relationship between the DMG and CG groups, even though there is no statistically difference between DMG and DPHG groups.
Conclusions: The result of the study demonstrated that receiving a 2.5-mL dose of honey before sleep has a more alleviating effect on URIs-induced cough compared with DM and DPH doses.
J Altern Complement Med. 2010 Jul 12. [Epub ahead of print]
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