年龄和性别对气道高反应性的影响
2010/09/14
摘要
目的：目前，对于年龄和性别与气道反应性的准确关系尚未明确。之前有关年龄和性别对气道反应性影响的研究受到混杂因素（如吸烟）的影响。本文旨在研究环境控制下（独立于混杂环境因素），C57BL/6小鼠的年龄和性别对气道反应性的影响。
方法：根据年龄和性别，小鼠分为4组：6周和12周雄性组及雌性组。对每组小鼠通过吸入乙酰甲胆碱检测气道反应性。
结果：相同年龄组不同性别的小鼠间，其乙酰甲胆碱诱发的气道反应显著不同。6周龄小鼠中，雄性小鼠较雌性小鼠对乙酰甲胆碱产生的气道反应性强（p <0.001）。相反的是，12周龄小鼠，雄性较雌性的气道反应性明显减弱（p <0.001）。因此，与雌性相比，雄性小鼠中年龄与气道反应性的关系在不同年龄呈现不同的相关性。对于相同性别、不同年龄的小鼠，雌性小鼠其气道反应性随年龄显著增加（p <0.001）。相反，雄性小鼠其气道反应性随年龄增加显著下降（p <0.001）。
结论：上述结果显示，不同年龄和性别的小鼠其气道反应性存在显著差异，该影响与环境因素无关。本研究也表明，在进行气道反应性相关研究中，不同分组的患者其年龄和性别需匹配。
（刘国梁 审校）
J Asthma. 2010 Jul 15. [Epub ahead of print]
Age and Sex Influences on Airway Hyperresponsiveness
McKenzie R, Burton MD, Royce SG, Tang ML.
Department of Allergy and Immunology, Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria, Australia.
Abstract
Objective.The precise relationship between age and gender and their influence on airway reactivity has not been clearly defined. Previous studies of age and gender influences on airway reactivity have been confounded by environmental influences such as cigarette smoking. The objective of this study was to examine the effect of age and gender on airway reactivity in C57BL/6 mice housed under controlled conditions, independent of confounding environmental factors.
Methods. Mice were separated into four experimental groups based on age and gender: males at 6 and 12 weeks of age and females at 6 and 12 weeks of age. Airway reactivity to inhaled methacholine was examined in each group.
Results.Significant differences in methacholine-induced airway reactivity were observed between the sexes at both age groups. At 6 weeks of age, the males demonstrated a significantly increased airway reactivity to methacholine as compared to females (p <.001). Paradoxically, at 12 weeks of age, the males demonstrated a significantly lower response to methacholine as compared to females (p <.001). Hence the relationship between age and airway reactivity is markedly different in males as compared to females. Examination of intragender differences revealed that in female mice, airway reactivity increased significantly with age (p <.001). In contrast, males demonstrated a significant reduction in airway reactivity with age (p <.001).
Conclusion. hese findings demonstrate important differences in airway reactivity related to age and gender that are observed independent of any environmental influences. Furthermore, these findings highlight the importance of careful age and sex matching in studies of airway reactivity.
J Asthma. 2010 Jul 15. [Epub ahead of print]
目的：目前，对于年龄和性别与气道反应性的准确关系尚未明确。之前有关年龄和性别对气道反应性影响的研究受到混杂因素（如吸烟）的影响。本文旨在研究环境控制下（独立于混杂环境因素），C57BL/6小鼠的年龄和性别对气道反应性的影响。
方法：根据年龄和性别，小鼠分为4组：6周和12周雄性组及雌性组。对每组小鼠通过吸入乙酰甲胆碱检测气道反应性。
结果：相同年龄组不同性别的小鼠间，其乙酰甲胆碱诱发的气道反应显著不同。6周龄小鼠中，雄性小鼠较雌性小鼠对乙酰甲胆碱产生的气道反应性强（p <0.001）。相反的是，12周龄小鼠，雄性较雌性的气道反应性明显减弱（p <0.001）。因此，与雌性相比，雄性小鼠中年龄与气道反应性的关系在不同年龄呈现不同的相关性。对于相同性别、不同年龄的小鼠，雌性小鼠其气道反应性随年龄显著增加（p <0.001）。相反，雄性小鼠其气道反应性随年龄增加显著下降（p <0.001）。
结论：上述结果显示，不同年龄和性别的小鼠其气道反应性存在显著差异，该影响与环境因素无关。本研究也表明，在进行气道反应性相关研究中，不同分组的患者其年龄和性别需匹配。
（刘国梁 审校）
J Asthma. 2010 Jul 15. [Epub ahead of print]
Age and Sex Influences on Airway Hyperresponsiveness
McKenzie R, Burton MD, Royce SG, Tang ML.
Department of Allergy and Immunology, Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria, Australia.
Abstract
Objective.The precise relationship between age and gender and their influence on airway reactivity has not been clearly defined. Previous studies of age and gender influences on airway reactivity have been confounded by environmental influences such as cigarette smoking. The objective of this study was to examine the effect of age and gender on airway reactivity in C57BL/6 mice housed under controlled conditions, independent of confounding environmental factors.
Methods. Mice were separated into four experimental groups based on age and gender: males at 6 and 12 weeks of age and females at 6 and 12 weeks of age. Airway reactivity to inhaled methacholine was examined in each group.
Results.Significant differences in methacholine-induced airway reactivity were observed between the sexes at both age groups. At 6 weeks of age, the males demonstrated a significantly increased airway reactivity to methacholine as compared to females (p <.001). Paradoxically, at 12 weeks of age, the males demonstrated a significantly lower response to methacholine as compared to females (p <.001). Hence the relationship between age and airway reactivity is markedly different in males as compared to females. Examination of intragender differences revealed that in female mice, airway reactivity increased significantly with age (p <.001). In contrast, males demonstrated a significant reduction in airway reactivity with age (p <.001).
Conclusion. hese findings demonstrate important differences in airway reactivity related to age and gender that are observed independent of any environmental influences. Furthermore, these findings highlight the importance of careful age and sex matching in studies of airway reactivity.
J Asthma. 2010 Jul 15. [Epub ahead of print]
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