门诊咳嗽评估：便携式自动咳嗽分析仪
2010/07/07
背景：咳嗽是严重肺部疾病的主要症状之一，然而，现有治疗方法疗效不尽如人意。新型止咳药的研发需对咳嗽进行客观评估。
方法：本研究测试一种新型便携式自动咳嗽分析仪的可行性。在13名慢性咳嗽患者，研究咳嗽主观评价和客观评价的相关性。患者的病史、咳嗽症状评分和数字式咳嗽量表（1-10）用于咳嗽主观评价，电脑控制的音频计时器用于检测咳嗽频率。
结果：临床前研究显示，自动咳嗽分析仪是门诊评价慢性咳嗽的准确、可靠手段。日间的临床研究显示，主观咳嗽评分与咳嗽分析仪记录的所有咳嗽（r=0.63;P=0.022）和每小时咳嗽次数（r=0.60; P=0.03）相关。然而，咳嗽评分与每小时咳嗽时间不具相关性（r=0.48; P=0.1）。夜间评估显示，主观咳嗽评分与每小时咳嗽次数（r=0.29; P=0.34）或咳嗽时间（r=0.26; P=0.4）不具相关性。
结论：自动咳嗽分析仪可作为咳嗽的门诊检测手段。日间咳嗽主观评价与客观评价存在一定相关性，而该相关性未见于夜间咳嗽评价，因此夜间主观分析可能不可靠。
（陈欣 审校）
Krajnik M, et al. Biomed Eng Online. 2010 Mar 14;9(1):17. [Epub ahead of print]
A portable automatic cough analyser in the ambulatory assessment of cough.
Krajnik M, Damps-Konstanska I, Gorska L, Jassem E.
ABSTRACT:
BACKGROUND: Cough is one of the main symptoms of advanced lung disease. However, the efficacy of currently available treatment remains unsatisfactory. Research into the new antitussives requires an objective assessment of cough.
METHOD: The aim of the study was to test the feasibility of a new automatic portable cough analyser and assess the correlation between subjective and objective evaluations of cough in 13 patients with chronic cough. The patients’ individual histories, a cough symptom score and a numeric cough scale (1-10) were used as a subjective evaluation of cough and a computerized audio-timed recorder was used to measure the frequency of coughing.
RESULTS: The pre-clinical validation has shown that an automated cough analyser is an accurate and reliable tool for the ambulatory assessment of chronic cough. In the clinical part of the experiment for the daytime, subjective cough scoring correlated with the number of all cough incidents recorded by the cough analyser (r = 0.63; p = 0.022) and the number of cough incidents per hour (r = 0.60; p = 0.03). However, there was no relation between cough score and the time spent coughing per hour (r = 0.48; p = 0.1). As assessed for the night-time period, no correlation was found between subjective cough scoring and the number of incidents per hour (r = 0.29; p = 0.34) or time spent coughing (r = 0.26; p = 0.4).
CONCLUSION: An automated cough analyser seems to be a feasible tool for the ambulatory monitoring of cough. There is a moderate correlation between subjective and objective assessments of cough during the daytime, whereas the discrepancy in the evaluation of night-time coughing might suggest that subjective analysis is unreliable.
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芬太尼诱导儿童咳嗽频率及其对气管插管的影响
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运动和自主性过度通气能抑制咳嗽
