儿童哮喘症状的感知及肥胖
2010/02/23
本试验在200例哮喘幼儿中研究肥胖与哮喘症状感知之间的关系。
反复检测主观和客观峰值流量，采用哮喘风险网格（Klein et al., 2004）进行总结，形成准确、症状放大及危险区评分。通过年龄和种族分层进行分析。
对于年幼儿童，肥胖与感知评分无明显相关性。对于年长儿童，准确症状感知评分在肥胖-种族之间存在的明显相互作用提示在白种人中，肥胖儿童对哮喘症状的感知程度低于非肥胖儿童，在少数民族儿童中则未观察到上述结果。对于年长儿童，不论哪个种族，肥胖与较高的症状放大评分相关。
上述结果表明，肥胖可能通过影响患者对哮喘症状的感知使哮喘的管理变得复杂化。尚需更多研究证实社会人口统计学因素在上述结果中的作用。
（刘国梁 审校）
Biol Psychol. 2009 Nov 23. [Epub ahead of print]
Asthma Symptom Perception and Obesity in Children.
Kopel SJ, Walders-Abramson N, McQuaid EL, Seifer R, Koinis-Mitchell D, Klein RB, Wamboldt MZ, Fritz GK.
Bradley Hasbro Research Center/Warren Alpert Medical School of Brown University, 1 Hoppin Street, Suite 204, Providence, Rhode Island 02903.
This study examined the relationship between obesity and asthma symptom perception in 200 youth with asthma. Repeated subjective and objective peak flow measurements were summarized using the Asthma Risk Grid (Klein et al., 2004), resulting in Accurate, Symptom Magnification and Danger Zone scores. Analyses were stratified by age and included ethnicity. For younger children, obesity was not significantly related to perception scores. For older children, a significant obesity-by-ethnicity interaction for Accurate symptom perception scores indicated that obese white children had lower accuracy than white nonobese children, while there was no difference for obese versus nonobese minority children. Obesity was also related to higher Symptom Magnification scores regardless of ethnicity for older children. Findings suggest that obesity may complicate asthma management by interfering with the ability to accurately perceive symptoms for some patients. More remains to be learned about the role of sociodemographic factors underlying this relationship.
Kopel SJ, Walders-Abramson N, McQuaid EL, et al. Biol Psychol. 2009 Nov 23. [Epub ahead of print]
反复检测主观和客观峰值流量，采用哮喘风险网格（Klein et al., 2004）进行总结，形成准确、症状放大及危险区评分。通过年龄和种族分层进行分析。
对于年幼儿童，肥胖与感知评分无明显相关性。对于年长儿童，准确症状感知评分在肥胖-种族之间存在的明显相互作用提示在白种人中，肥胖儿童对哮喘症状的感知程度低于非肥胖儿童，在少数民族儿童中则未观察到上述结果。对于年长儿童，不论哪个种族，肥胖与较高的症状放大评分相关。
上述结果表明，肥胖可能通过影响患者对哮喘症状的感知使哮喘的管理变得复杂化。尚需更多研究证实社会人口统计学因素在上述结果中的作用。
（刘国梁 审校）
Biol Psychol. 2009 Nov 23. [Epub ahead of print]
Asthma Symptom Perception and Obesity in Children.
Kopel SJ, Walders-Abramson N, McQuaid EL, Seifer R, Koinis-Mitchell D, Klein RB, Wamboldt MZ, Fritz GK.
Bradley Hasbro Research Center/Warren Alpert Medical School of Brown University, 1 Hoppin Street, Suite 204, Providence, Rhode Island 02903.
This study examined the relationship between obesity and asthma symptom perception in 200 youth with asthma. Repeated subjective and objective peak flow measurements were summarized using the Asthma Risk Grid (Klein et al., 2004), resulting in Accurate, Symptom Magnification and Danger Zone scores. Analyses were stratified by age and included ethnicity. For younger children, obesity was not significantly related to perception scores. For older children, a significant obesity-by-ethnicity interaction for Accurate symptom perception scores indicated that obese white children had lower accuracy than white nonobese children, while there was no difference for obese versus nonobese minority children. Obesity was also related to higher Symptom Magnification scores regardless of ethnicity for older children. Findings suggest that obesity may complicate asthma management by interfering with the ability to accurately perceive symptoms for some patients. More remains to be learned about the role of sociodemographic factors underlying this relationship.
Kopel SJ, Walders-Abramson N, McQuaid EL, et al. Biol Psychol. 2009 Nov 23. [Epub ahead of print]
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哮喘如何影响儿童日常生活？来自于焦点小组访谈的结果
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不同喘息表现型的4岁儿童肺功能和对支气管扩张剂的反应
