急性咳嗽：诊断和治疗挑战
2010/02/03
背景：急性咳嗽是促使患者就诊的最常见症状。尽管急性咳嗽对患者的生活质量、学习和工作及公共医疗资源都有重要影响，但对急性咳嗽的研究却很少，且仅限于现有的治疗方案。许多患者采用非处方药治疗，但不能有效缓解症状。某些治疗方法虽能止咳，但具有令人不快或难以忍受的副作用。
未满足的需求：目前已有的急性咳嗽治疗方法，存在多种明显的局限性。大部分治疗方法未能在临床实践中证实其有效性及可靠性。因此，有必要进行更为科学的临床试验，收集高质量的数据。希望这些试验有助于开发出更安全、有效、可靠的急性咳嗽治疗方法。
咳嗽评价及处理：急性咳嗽原因很多，因此，有必要对这些致病因素进行仔细检查。此外，掌握急性咳嗽对患者生活质量、工作及医疗系统的影响也十分重要。了解这些影响因素有助于更好地理解咳嗽的社会影响。关于目前已有的急性咳嗽的治疗方法，充分了解市场非处方药及处方药类型、作用机制及其优缺点，有助于采取更多的药物治疗机会和更好的临床决策。然而，由于目前治疗方案的缺陷，需要对新的药物和治疗方法进行开发和检测，以有效治疗咳嗽。
结论：鉴于急性咳嗽有着巨大的社会-经济学影响，以及现有治疗措施的局限性，有必要对急性咳嗽的治疗进行进一步深入研究。目前需要对急性咳嗽的治疗策略进行重新评价，以开发出新的、可靠的、有效且安全的药物和治疗方案。
（刘国梁 审校）
Cough. 2009 Dec 16;5(1):11. [Epub ahead of print]
Acute cough: a diagnostic and therapeutic challenge.
Dicpinigaitis PV, Colice GL, Goolsby MJ, Rogg GI, Spector SL, Winther B.
Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
ABSTRACT: BACKGROUND: Acute cough is one of the most common complaints prompting patient visits to healthcare professionals. Despite the broad repercussions of acute cough on patient quality of life, school and work productivity, and public health resources, research on this condition is minimal, as are the available treatment options. Many patients use over-the-counter medicines, which are often ineffective for symptom relief. Some therapies may achieve antitussive activity, but at the expense of unpleasant or intolerable side effects. Unmet needs When considering the treatments currently available for the management of acute cough, the multiple limitations of such treatments are quite apparent. Most of these treatments lack clinically proven efficacy and reliability to support their use. This reinforces the need for the generation of quality scientific data from well-performed clinical trials. Hopefully, the result will be the development of safer, more effective and more reliable therapeutic options in the management of acute cough. Cough assessment and management Acute cough can be due to a variety of causes, and it is worthwhile to consider these pathogenic factors in some detail. It is also important to be familiar with the effects that acute cough has on patients’ quality of life, work productivity, and the healthcare system; proper awareness of these effects may contribute to better understanding of the social impact of cough. In reference to the available treatments for the management of acute cough, adequate knowledge of the type of over-the-counter and prescription products in the market, as well as their mode of action and advantages/disadvantages, may provide expanded pharmacotherapeutic opportunities and facilitate better clinical decisions. However, due to the drawbacks of current treatment options, ideas for future cough management and newer products need to be considered and tested.
CONCLUSION: In view of the socio-economic impact of acute cough and the limitations of available treatments, a renewed interest in the management of acute cough needs to be encouraged. The current strategies for acute cough management need to be reassessed, with a focus on developing new, reliable products and formulations with proven efficacy and safety.
Dicpinigaitis PV, et al. Cough. 2009 Dec 16;5(1):11. [Epub ahead of print]
未满足的需求：目前已有的急性咳嗽治疗方法，存在多种明显的局限性。大部分治疗方法未能在临床实践中证实其有效性及可靠性。因此，有必要进行更为科学的临床试验，收集高质量的数据。希望这些试验有助于开发出更安全、有效、可靠的急性咳嗽治疗方法。
咳嗽评价及处理：急性咳嗽原因很多，因此，有必要对这些致病因素进行仔细检查。此外，掌握急性咳嗽对患者生活质量、工作及医疗系统的影响也十分重要。了解这些影响因素有助于更好地理解咳嗽的社会影响。关于目前已有的急性咳嗽的治疗方法，充分了解市场非处方药及处方药类型、作用机制及其优缺点，有助于采取更多的药物治疗机会和更好的临床决策。然而，由于目前治疗方案的缺陷，需要对新的药物和治疗方法进行开发和检测，以有效治疗咳嗽。
结论：鉴于急性咳嗽有着巨大的社会-经济学影响，以及现有治疗措施的局限性，有必要对急性咳嗽的治疗进行进一步深入研究。目前需要对急性咳嗽的治疗策略进行重新评价，以开发出新的、可靠的、有效且安全的药物和治疗方案。
（刘国梁 审校）
Cough. 2009 Dec 16;5(1):11. [Epub ahead of print]
Acute cough: a diagnostic and therapeutic challenge.
Dicpinigaitis PV, Colice GL, Goolsby MJ, Rogg GI, Spector SL, Winther B.
Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
ABSTRACT: BACKGROUND: Acute cough is one of the most common complaints prompting patient visits to healthcare professionals. Despite the broad repercussions of acute cough on patient quality of life, school and work productivity, and public health resources, research on this condition is minimal, as are the available treatment options. Many patients use over-the-counter medicines, which are often ineffective for symptom relief. Some therapies may achieve antitussive activity, but at the expense of unpleasant or intolerable side effects. Unmet needs When considering the treatments currently available for the management of acute cough, the multiple limitations of such treatments are quite apparent. Most of these treatments lack clinically proven efficacy and reliability to support their use. This reinforces the need for the generation of quality scientific data from well-performed clinical trials. Hopefully, the result will be the development of safer, more effective and more reliable therapeutic options in the management of acute cough. Cough assessment and management Acute cough can be due to a variety of causes, and it is worthwhile to consider these pathogenic factors in some detail. It is also important to be familiar with the effects that acute cough has on patients’ quality of life, work productivity, and the healthcare system; proper awareness of these effects may contribute to better understanding of the social impact of cough. In reference to the available treatments for the management of acute cough, adequate knowledge of the type of over-the-counter and prescription products in the market, as well as their mode of action and advantages/disadvantages, may provide expanded pharmacotherapeutic opportunities and facilitate better clinical decisions. However, due to the drawbacks of current treatment options, ideas for future cough management and newer products need to be considered and tested.
CONCLUSION: In view of the socio-economic impact of acute cough and the limitations of available treatments, a renewed interest in the management of acute cough needs to be encouraged. The current strategies for acute cough management need to be reassessed, with a focus on developing new, reliable products and formulations with proven efficacy and safety.
Dicpinigaitis PV, et al. Cough. 2009 Dec 16;5(1):11. [Epub ahead of print]
上一篇：
高保真度咳嗽声响及气流特征记录系统
下一篇：
反流性咳嗽新进展
