在支气管哮喘中高敏感性C反应蛋白与痰液细胞计数的关系
2009/12/15
背景：目前在人体发现两个急性相蛋白，即C反应蛋白和血清淀粉样蛋白A。C反应蛋白共分为3类：传统的C反应蛋白，高敏感性C反应蛋白和心肌C反应蛋白。高敏感性C反应蛋白能检测到微小炎症变化，后者一般会被其它的炎症指标所忽视。诱导的痰液细胞计数是一项用于诊断哮喘患者气道炎症存在与否及炎症类型的无创性、安全可靠的方法。
研究目的：本试验旨在研究血清高敏感性C反应蛋白在哮喘患者中的作用，不管患者是否接受糖皮质激素吸入治疗。同时，研究血清高敏感性C反应蛋白水平与哮喘临床指标及诱导痰液的炎症细胞计数之间的关系。
研究对象及方法：对50名哮喘患者（26名糖皮质激素吸入治疗患者，24名无糖皮质激素吸入治疗）检测血清高敏感性C反应蛋白、肺功能、体重指数及诱导痰液细胞计数。15名年龄和性别匹配的健康志愿者作为对照组。
结果：与健康对照相比，哮喘患者不管是否采用糖皮质激素吸入治疗，其血清高敏感C反应蛋白显著升高，后者在有或无糖皮质激素吸入治疗的哮喘患者中，与肺功能成负相关，与痰液嗜酸性粒细胞百分比成正相关。
结论：高敏感C反应蛋白是系统性炎症的标志物之一，能间接反应支气管哮喘患者气道炎症程度。
（林江涛 审校）
Respir Med. 2009 Oct 15.
High sensitivity C-reactive protein: Its correlation with sputum cell counts in bronchial asthma.
Allam MH, Said AF, El Samie Omran AA, Abd El-Reheim DM, Kasem AH.
BACKGROUND: Two major acute-phase proteins were identified in human, C-reactive protein and serum amyloid A. There are 3 types of C-reactive protein assays: conventional C-reactive protein, high sensitivity C-reactive protein and cardiac C-reactive protein. High sensitivity C-reactive protein assays can detect minor inflammatory changes that could be missed by other indices of inflammation. Induced sputum cell counts are relatively non-invasive, safe and reliable method for identifying the presence and type of airway inflammation in asthmatic patients. PURPOSE OF THE WORK: This study was designed to detect the role of serum levels of high sensitivity C-reactive protein in asthmatic patients with or without inhaled corticosteroids treatment. Also to determine the relationship of serum high sensitivity C-reactive protein levels to clinical indices of asthma and inflammatory cell counts in induced sputum.
SUBJECTS & METHODS: Serum high sensitivity C-reactive protein level, pulmonary function tests, body mass index and induced sputum cell counts were estimated in 50 asthmatic patients (26 steroid inhaled and 24 steroid naïve). Fifteen healthy volunteers, who matched in age and sex with the other groups, were used as a control group.
RESULTS: There was an increase of high sensitivity C-reactive protein in asthmatic patients among both steroid inhaled and steroid naïve patients compared to the healthy controls. Serum high sensitivity C-reactive protein correlated negatively with pulmonary function tests and positively with sputum eosinophil % in both inhaled steroid and steroid naïve groups.
CONCLUSION: High sensitivity C-reactive protein is one of the markers of systemic inflammation that can be indirectly reflecting the degree of severity of airway inflammation in bronchial asthma.
Allam MH, Said AF, El Samie Omran AA, Respir Med. 2009 Oct 15.）
研究目的：本试验旨在研究血清高敏感性C反应蛋白在哮喘患者中的作用，不管患者是否接受糖皮质激素吸入治疗。同时，研究血清高敏感性C反应蛋白水平与哮喘临床指标及诱导痰液的炎症细胞计数之间的关系。
研究对象及方法：对50名哮喘患者（26名糖皮质激素吸入治疗患者，24名无糖皮质激素吸入治疗）检测血清高敏感性C反应蛋白、肺功能、体重指数及诱导痰液细胞计数。15名年龄和性别匹配的健康志愿者作为对照组。
结果：与健康对照相比，哮喘患者不管是否采用糖皮质激素吸入治疗，其血清高敏感C反应蛋白显著升高，后者在有或无糖皮质激素吸入治疗的哮喘患者中，与肺功能成负相关，与痰液嗜酸性粒细胞百分比成正相关。
结论：高敏感C反应蛋白是系统性炎症的标志物之一，能间接反应支气管哮喘患者气道炎症程度。
（林江涛 审校）
Respir Med. 2009 Oct 15.
High sensitivity C-reactive protein: Its correlation with sputum cell counts in bronchial asthma.
Allam MH, Said AF, El Samie Omran AA, Abd El-Reheim DM, Kasem AH.
BACKGROUND: Two major acute-phase proteins were identified in human, C-reactive protein and serum amyloid A. There are 3 types of C-reactive protein assays: conventional C-reactive protein, high sensitivity C-reactive protein and cardiac C-reactive protein. High sensitivity C-reactive protein assays can detect minor inflammatory changes that could be missed by other indices of inflammation. Induced sputum cell counts are relatively non-invasive, safe and reliable method for identifying the presence and type of airway inflammation in asthmatic patients. PURPOSE OF THE WORK: This study was designed to detect the role of serum levels of high sensitivity C-reactive protein in asthmatic patients with or without inhaled corticosteroids treatment. Also to determine the relationship of serum high sensitivity C-reactive protein levels to clinical indices of asthma and inflammatory cell counts in induced sputum.
SUBJECTS & METHODS: Serum high sensitivity C-reactive protein level, pulmonary function tests, body mass index and induced sputum cell counts were estimated in 50 asthmatic patients (26 steroid inhaled and 24 steroid naïve). Fifteen healthy volunteers, who matched in age and sex with the other groups, were used as a control group.
RESULTS: There was an increase of high sensitivity C-reactive protein in asthmatic patients among both steroid inhaled and steroid naïve patients compared to the healthy controls. Serum high sensitivity C-reactive protein correlated negatively with pulmonary function tests and positively with sputum eosinophil % in both inhaled steroid and steroid naïve groups.
CONCLUSION: High sensitivity C-reactive protein is one of the markers of systemic inflammation that can be indirectly reflecting the degree of severity of airway inflammation in bronchial asthma.
Allam MH, Said AF, El Samie Omran AA, Respir Med. 2009 Oct 15.）
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