哮喘和COPD中炎症机制的差异
2009/11/17
支气管哮喘和慢性阻塞性肺疾病（COPD）为常见疾病，且其发病率在逐渐上升。两者的主要致病机制均为慢性炎症。然而，两者的炎症表现形式并不一样。在哮喘患者的气道中，主要为活化的肥大细胞/嗜酸性粒细胞和Th2淋巴细胞。相反，在COPD患者的气道/肺，主要为巨噬细胞和中性粒细胞。虽然哮喘和COPD患者均存在由诱导型一氧化氮合成酶（iNOS）催化的一氧化氮（NO）过度产生，但是，硝基酪氨酸主要通过除髓过氧化物酶介导途径之外的NO和超氧阴离子反应形成。这些不同的炎症形式可能导致哮喘和COPD的病理学差异。
（ 陈欣 审校）
Allergol Int. 2009 Sep;58(3):307-13. Epub 2009 Jul 25.
Differences of inflammatory mechanisms in asthma and COPD.
Ichinose M.
Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. masakazu@wakayama-med.ac.jp
Bronchial asthma and chronic obstructive pulmonary disease (COPD) are increasing common diseases. The major pathogenesis of both illnesses is chronic inflammation. However, the inflammatory pattern is distinct in each disease. In asthmatic airways, activated mast cells/eosinophils and T helper 2 lymphocytes (Th2) are predominant. In contrast, macrophages and neutrophils are important in COPD airways/lung. Although nitric oxide (NO) hyperproduction due to inducible NO synthase (iNOS) is observed in asthma and COPD, nitrotyrosine formation via the reaction between NO and O(2)- in addition to the myeloperoxidase-mediated pathway. These distinct inflammatory patterns in both diseases seem to cause pathological differences in asthma and COPD.
Allergol Int. 2009 Sep;58(3):307-13. Epub 2009 Jul 25.
（ 陈欣 审校）
Allergol Int. 2009 Sep;58(3):307-13. Epub 2009 Jul 25.
Differences of inflammatory mechanisms in asthma and COPD.
Ichinose M.
Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. masakazu@wakayama-med.ac.jp
Bronchial asthma and chronic obstructive pulmonary disease (COPD) are increasing common diseases. The major pathogenesis of both illnesses is chronic inflammation. However, the inflammatory pattern is distinct in each disease. In asthmatic airways, activated mast cells/eosinophils and T helper 2 lymphocytes (Th2) are predominant. In contrast, macrophages and neutrophils are important in COPD airways/lung. Although nitric oxide (NO) hyperproduction due to inducible NO synthase (iNOS) is observed in asthma and COPD, nitrotyrosine formation via the reaction between NO and O(2)- in addition to the myeloperoxidase-mediated pathway. These distinct inflammatory patterns in both diseases seem to cause pathological differences in asthma and COPD.
Allergol Int. 2009 Sep;58(3):307-13. Epub 2009 Jul 25.
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嗜酸性粒细胞性支气管炎和哮喘患者支气管肺泡灌洗液中的8-异前列腺素含量
