美国儿童和青少年肥胖与哮喘的关系
2009/11/17
背景：在校正结构性和行为学因素后，研究美国儿童和青少年肥胖与哮喘的相关性。
方法：在《美国全国儿童健康调查（2003-2004）》中，对102,273 名儿童和青少年的哮喘发病率和相关危险因素进行调查。同时，对研究对象进行年龄分层分析（0-6岁, 7-12岁及13-17岁）。采用单变量和多变量logistic回归分析检测原始优势比和校正优势比。
结果：肥胖的总体患病率为23.5％，哮喘患病率为12.5％。在7-12岁及13-17岁年龄组中，哮喘与肥胖的校正优势比显著大于1。所有年龄组患儿的性别和种族均与哮喘显著相关。在0-6岁年龄组儿童中，双亲家庭结构对避免哮喘发生具有显著的保护性作用。在7-12岁年龄组患儿中，贫困与哮喘成正相关性。家庭吸烟会增加哮喘的发生风险（0-6岁和13-17岁年龄组人群分别增加29％和23.5％）。双亲的受教育程度和医疗保健程度与13-17岁年龄组儿童的哮喘发病率成正相关性。
结论：性别和年龄与哮喘显著相关。13-17岁组患儿中，肥胖、父母受教育程度、医疗保险及家庭吸烟与哮喘成正相关性。目前，尚需更多的试验来研究家庭结构和父母受教育程度是怎样分别对0-6岁和13-17岁年龄组儿童的哮喘发生产生影响的。
（陈欣 审校）
J Asthma. 2009 Sep;46(7):642-646.
Association between obesity and asthma in US children and adolescents.
Ahmad N, Biswas S, Bae S, Meador KE, Huang R, Singh KP.
BACKGROUND: To explore the association between obesity and asthma in US children and adolescents with adjustment of other structural and behavioral factors.
METHOD: Prevalence and associated risk factors of asthma were explored in 102,273 children and adolescents in the National Survey of Children’s Health (2003-2004). Subgroup analysis was performed for subjects of 0-6 year-old, 7-12 year-old, and 13-17 year-old. Crude and adjusted odds ratios for the potential risk factors were examined in univariate and multivariate logistic regressions.
RESULTS: The overall prevalence of obesity was 24.5% and that of asthma was 12.5%. The adjusted odds ratio of asthma with obesity remains significantly bigger than 1 for children in the 7-12 and the 13-17 year-old age-groups. Gender and race were significantly associated with asthma in all age groups. The two parent family structure showed significant protectiveness against asthma with children in the 0-6 year-old age group. Poverty was positively associated with asthma in the 7-12 years old age group. Having a smoker in the household increased the odds of asthma by 29% and 23.5% in the 0-6 and 13-17 year-old age-groups, respectively. Higher education level of the parents and access to healthcare showed positive association with asthma in the 13-17 year-old age group.
CONCLUSION: Gender and race were significantly associated with asthma. In the 13-17 year-old age-groups, obesity, household education level, healthcare coverage, and household smoking were positively associated with asthma. Further studies should characterize how the family structure and household education level influence childhood asthma in 0-6 and 13-17 year-old age-groups respectively
J Asthma. 2009 Sep;46(7):642-6.
方法：在《美国全国儿童健康调查（2003-2004）》中，对102,273 名儿童和青少年的哮喘发病率和相关危险因素进行调查。同时，对研究对象进行年龄分层分析（0-6岁, 7-12岁及13-17岁）。采用单变量和多变量logistic回归分析检测原始优势比和校正优势比。
结果：肥胖的总体患病率为23.5％，哮喘患病率为12.5％。在7-12岁及13-17岁年龄组中，哮喘与肥胖的校正优势比显著大于1。所有年龄组患儿的性别和种族均与哮喘显著相关。在0-6岁年龄组儿童中，双亲家庭结构对避免哮喘发生具有显著的保护性作用。在7-12岁年龄组患儿中，贫困与哮喘成正相关性。家庭吸烟会增加哮喘的发生风险（0-6岁和13-17岁年龄组人群分别增加29％和23.5％）。双亲的受教育程度和医疗保健程度与13-17岁年龄组儿童的哮喘发病率成正相关性。
结论：性别和年龄与哮喘显著相关。13-17岁组患儿中，肥胖、父母受教育程度、医疗保险及家庭吸烟与哮喘成正相关性。目前，尚需更多的试验来研究家庭结构和父母受教育程度是怎样分别对0-6岁和13-17岁年龄组儿童的哮喘发生产生影响的。
（陈欣 审校）
J Asthma. 2009 Sep;46(7):642-646.
Association between obesity and asthma in US children and adolescents.
Ahmad N, Biswas S, Bae S, Meador KE, Huang R, Singh KP.
BACKGROUND: To explore the association between obesity and asthma in US children and adolescents with adjustment of other structural and behavioral factors.
METHOD: Prevalence and associated risk factors of asthma were explored in 102,273 children and adolescents in the National Survey of Children’s Health (2003-2004). Subgroup analysis was performed for subjects of 0-6 year-old, 7-12 year-old, and 13-17 year-old. Crude and adjusted odds ratios for the potential risk factors were examined in univariate and multivariate logistic regressions.
RESULTS: The overall prevalence of obesity was 24.5% and that of asthma was 12.5%. The adjusted odds ratio of asthma with obesity remains significantly bigger than 1 for children in the 7-12 and the 13-17 year-old age-groups. Gender and race were significantly associated with asthma in all age groups. The two parent family structure showed significant protectiveness against asthma with children in the 0-6 year-old age group. Poverty was positively associated with asthma in the 7-12 years old age group. Having a smoker in the household increased the odds of asthma by 29% and 23.5% in the 0-6 and 13-17 year-old age-groups, respectively. Higher education level of the parents and access to healthcare showed positive association with asthma in the 13-17 year-old age group.
CONCLUSION: Gender and race were significantly associated with asthma. In the 13-17 year-old age-groups, obesity, household education level, healthcare coverage, and household smoking were positively associated with asthma. Further studies should characterize how the family structure and household education level influence childhood asthma in 0-6 and 13-17 year-old age-groups respectively
J Asthma. 2009 Sep;46(7):642-6.
上一篇：
社会和环境应激因子在家庭和儿童期哮喘中的作用
下一篇：
哮喘与ABO血型无关
