能否通过住房环境指数建立室内风险指标与哮喘患者临床检测之间的关系？
2009/09/16
该研究目的为调查经室内风险指标（鉴定的住房环境指数(HE-index)）与哮喘患者临床检测结果（如肺功能、过敏反应以及支气管高反应性(BHR)）之间的关系。
调查共纳入49名合格患者。HE指数基于国家及国际指南，检测内容包括湿度、温度、二氧化碳、甲醛、二氧化氮、过敏原、烟草烟雾以及宠物等。仅18％的受调查家庭中未见任何危险指标。统计学显示，尘螨与肺功能显著相关，与宠物生活的人群中，BHR程度相对较轻。HE指数的截点水平并不与健康特异性相关，而敏感患者中该指数相对较高。目前，还需更多研究来确定与哮喘患者有关的住房环境危险指标，以制定相关指南。
（林江涛审校）
Frisk ML, Stridh G, Ivarsson AB, et al.
Int J Environ Health Res. 2009 Jul 3:1-16. [Epub ahead of print]
Can a housing environmental index establish associations between indoor risk indicators and clinical tests in persons with asthma?
Frisk ML, Stridh G, Ivarsson AB, Kamwendo K.
Department of Respiratory Medicine, Orebro University Hospital, Orebro, Sweden.
The aim was to investigate the associations between indoor risk indicators, identified by a housing environmental index (HE-index), and clinical tests of lung function, allergy and bronchial hyper-responsiveness (BHR). Forty-nine eligible subjects participated in the investigation. The HE-index was based on national and international guidelines and related to measurements of humidity, temperature, carbon dioxide, formaldehyde, nitrogen dioxide, allergens and occurrence of tobacco smoke and pets. Only 18% of the investigated homes did not have any of the risk indicators. Statistically significant associations were found between exposure to mites and lung function, and to a lesser degree in BHR for subjects living in homes with pets. The cut-off levels in the HE-index were not specifically related to health effects and may therefore have been too high for sensitive persons. Further studies are needed to establish relevant guidelines for the identification of risk indicators in the housing environment for persons with asthma.
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甘露醇和运动激发试验在哮喘患儿中的应用
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