哮喘联盟

    背景：白介素17A（IL17A）基因定位于染色体6p，与哮喘表现型有关，是哮喘易感性的重要潜在候选基因。本试验研究台湾儿童IL17A单核苷酸多态性（SNPs）与哮喘之间的关系。
    方法：选取有或无哮喘的台湾儿童，对其IL17A 基因组区域9个SNPs基因型进行检测。总计1939人入选，1027人为检测组，931人为验证组。
    结果：经过Bonferroni校正，基因型频率检测发现哮喘表现型与SNP rs8193036具有较弱的相关性（P = 0.0074 x 9 = 0.066）。这一相关性在验证组得到确认。过敏性共患病及性别校正后，Logistic回归显示相关性减弱。
    结论：研究结果显示台湾人群中，IL17A启动子多态性rs8193036作为一个独立因素，与儿童哮喘相关。

（刘国梁 审校）
Wang JY, et al. Allergy. 2009 Feb 5. [Epub ahead of print]

The polymorphisms of interleukin 17A (IL17A) gene and its association with pediatric asthma in Taiwanese population.

Background: The interleukin 17A (IL17A) gene, located on chromosome 6p and linked to asthma phenotype, is a highly potential candidate gene conferring asthma susceptibility. The purpose of this study was to investigate the genetic association between single nucleotide polymorphisms (SNPs) of IL17A and asthma in Taiwanese children.
Methods: We selected and performed genotyping on nine SNPs that encompass the genomic region of IL17A in Taiwanese children with or without asthma. A total of 1939 subjects containing 1027 subjects in testing group and 931 subjects in validation group were recruited in this study.
Results: After Bonferroni correction, SNP rs8193036 was found to have a weak association (P = 0.0074 x 9 = 0.066) in genotype frequency test. This association was confirmed by validation group. Logistic regression adjusted allergy comorbidity and gender showed a slightly weaker association.
Conclusions: The results indicated an independent role of IL17A promoter polymorphism rs8193036 in the association with pediatric asthma in Taiwanese population.