吸入突发事件和呼吸健康：欧洲共同体呼吸健康调查的结果
2009/03/27
背景：吸入突发事件是引起急性呼吸症状的重要原因，但是关于这些突发事件如何影响长期的呼吸健康我们还不甚了解。
方法：我们评估了欧洲共同体呼吸健康调查（ECRHS）中3,763名有或无咳嗽、咳痰、哮喘、喘息或支气管高反应性的研究对象中吸入突发事件的发生情况。然后我们检测在ECRHS基线调查时无上述5种症状的2,809名研究对象中其吸入性突发事件是否与在9年的ECRHS随访期间新近出现这些呼吸症状中任何一种有关。
结果：5%的研究对象出现吸入突发事件，在基线调查时有哮喘相关症状的研究对象中吸入突发事件发生率较高。在基线调查时无症状的研究对象中，我们的分析表明与无吸入突发事件的研究对象相比，有吸入突发事件的研究对象其咳嗽、咳痰、哮喘和喘息的风险增高无统计学意义，支气管高反应性的风险降低也无统计学意义。
结论：本研究结果为吸入性突发事件和哮喘相关症状相关提供了有限的证据。根据基线检查时的症状情况这些数据可能受吸入突发事件报道的差异影响，因此应谨慎解释这些数据。
（张永明 审校）
Mirabelli MC, et al. Am J Ind Med. 2009 Jan;52(1):17-24.
Mirabelli MC, et al. Am J Ind Med. 2009 Jan;52(1):17-24. Links
Inhalation incidents and respiratory health: results from the European Community Respiratory Health Survey.
BACKGROUND: Inhalation incidents are an important cause of acute respiratory symptoms, but little is known about how these incidents affect chronic respiratory health.
METHODS: We assessed reported inhalation incidents among 3,763 European Community Respiratory Health Survey (ECRHS) participants with and without cough, phlegm, asthma, wheezing or bronchial hyperresponsiveness. We then examined whether inhalation incidents during the 9-year ECRHS follow-up period were associated with a new onset of any of these respiratory outcomes among 2,809 participants who were free of all five outcomes at the time of the baseline ECRHS survey.
RESULTS: Inhalation incidents were reported by 5% of participants, with higher percentages reported among individuals with asthma-related outcomes at the time of the baseline survey. Among participants without symptoms at baseline, our analyses generated non-statistically significant elevated estimates of the risk of cough, phlegm, asthma and wheezing and a non-statistically significant inverse estimate of the risk of bronchial hyperresponsiveness among participants who reported an inhalation incident compared to those without such an event reported.
DISCUSSION: Our findings provide limited evidence of an association between inhalation incidents and asthma-related symptoms. These data could be affected by differences in the reporting of inhalation incidents according to symptom status at the time of the baseline survey; they should thus be interpreted with caution.
方法：我们评估了欧洲共同体呼吸健康调查（ECRHS）中3,763名有或无咳嗽、咳痰、哮喘、喘息或支气管高反应性的研究对象中吸入突发事件的发生情况。然后我们检测在ECRHS基线调查时无上述5种症状的2,809名研究对象中其吸入性突发事件是否与在9年的ECRHS随访期间新近出现这些呼吸症状中任何一种有关。
结果：5%的研究对象出现吸入突发事件，在基线调查时有哮喘相关症状的研究对象中吸入突发事件发生率较高。在基线调查时无症状的研究对象中，我们的分析表明与无吸入突发事件的研究对象相比，有吸入突发事件的研究对象其咳嗽、咳痰、哮喘和喘息的风险增高无统计学意义，支气管高反应性的风险降低也无统计学意义。
结论：本研究结果为吸入性突发事件和哮喘相关症状相关提供了有限的证据。根据基线检查时的症状情况这些数据可能受吸入突发事件报道的差异影响，因此应谨慎解释这些数据。
（张永明 审校）
Mirabelli MC, et al. Am J Ind Med. 2009 Jan;52(1):17-24.
Mirabelli MC, et al. Am J Ind Med. 2009 Jan;52(1):17-24. Links
Inhalation incidents and respiratory health: results from the European Community Respiratory Health Survey.
BACKGROUND: Inhalation incidents are an important cause of acute respiratory symptoms, but little is known about how these incidents affect chronic respiratory health.
METHODS: We assessed reported inhalation incidents among 3,763 European Community Respiratory Health Survey (ECRHS) participants with and without cough, phlegm, asthma, wheezing or bronchial hyperresponsiveness. We then examined whether inhalation incidents during the 9-year ECRHS follow-up period were associated with a new onset of any of these respiratory outcomes among 2,809 participants who were free of all five outcomes at the time of the baseline ECRHS survey.
RESULTS: Inhalation incidents were reported by 5% of participants, with higher percentages reported among individuals with asthma-related outcomes at the time of the baseline survey. Among participants without symptoms at baseline, our analyses generated non-statistically significant elevated estimates of the risk of cough, phlegm, asthma and wheezing and a non-statistically significant inverse estimate of the risk of bronchial hyperresponsiveness among participants who reported an inhalation incident compared to those without such an event reported.
DISCUSSION: Our findings provide limited evidence of an association between inhalation incidents and asthma-related symptoms. These data could be affected by differences in the reporting of inhalation incidents according to symptom status at the time of the baseline survey; they should thus be interpreted with caution.
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