慢性鼻窦炎伴鼻息肉的患者中支气管高反应性的预测因子
2009/03/27
背景：慢性鼻窦炎伴鼻息肉（CRSNP）和哮喘是呼吸道上皮的炎性损害。本研究旨在评价CRSNP患者支气管高反应性（BHR）的预测因子。
方法：采用乙酰甲胆碱支气管激发试验（MBPT）评价2004年1月～2006年6月间在首尔国立大学医院最近确诊患有CRSNP的122例连续病例的BHP。分析以下参数：症状、特应反应状态、现在吸烟、根据鼻窦CT的Lund-Mackay 评分系统确定的 CRSNP的疾病严重程度及血清和鼻组织中的嗜酸性粒细胞计数，并在BHP组和非BHP组间比较这些参数。
结果：35%的患者有BHR，且BHR在目前患有喷嚏的患者中更常见（P = 0.007）。此外，血清和鼻组织中的嗜酸性粒细胞计数的平均值BHR组高于非BHR组（血清P = 0.001，鼻组织P = 0.045），且血清嗜酸性粒细胞计数与鼻组织嗜酸性粒细胞计数相关（r = 0.334, P = 0.013）。两组比较，Lund-Mackay 评分系统确定的疾病严重程度无差异（P > 0.05）。CRSNP患者中预测BHR的最佳的血清嗜酸性粒细胞计数界值为300个细胞/微升（敏感度为70%，特异度为70%）。
结论：总的说来，这些结果表明中重度喷嚏和血清嗜酸性粒细胞计数≥300个细胞/微升可能是CRSNP患者中BHR的预测因子。
（张永明 审校）
Han DH, et al. Allergy. 2009 Jan;64(1):118-22. Epub 2008 Dec 17. Links
Han DH, et al. Allergy. 2009 Jan;64(1):118-22. Epub 2008 Dec 17. Links
Predictors of bronchial hyperresponsiveness in chronic rhino sinusitis with nasal polyp.
BACKGROUND: Chronic rhinosinusitis with nasal polyposis (CRSNP) and asthma are inflammatory lesions of the respiratory epithelium. This study was conducted to evaluate predictive factors of bronchial hyperresponsiveness (BHR) in patients with CRSNP.
METHODS: BHR was evaluated using a methacholine bronchoprovocation test (MBPT) in 122 consecutive patients newly diagnosed with CRSNP at Seoul National University Hospital from January 2004 to June 2006. The following parameters were analyzed and compared between the BHR and non-BHR groups: symptoms, atopic status, current smoking, disease severity of CRSNP based on the Lund-Mackay scoring system of sinus CT, and counts of eosinophils in the serum and nasal tissues.
RESULTS: Thirty-five percent of the patients were found to have BHR, and BHR was found to occur more frequently in patients that were currently suffering from sneezing (P = 0.007). In addition, the mean eosinophil counts of the serum and nasal tissues were higher in the BHR group than in the non-BHR group (P = 0.001 for the serum, P = 0.045 for the nasal tissues), and the eosinophil counts of the serum correlated to those of the nasal tissues (r = 0.334, P = 0.013). The disease severity, as determined by the Lund-Mackay scoring system, was not different between the two groups (P > 0.05). The best cutoff serum eosinophil count for predicting BHR in CRSNP patients was determined to be 300 cells/microl (sensitivity 70%, specificity 70%).
CONCLUSION: Taken together, these results indicate that moderate to severe sneezing and a serum eosinophil count > or = 300 cells/microl may be predictive factors for BHR in patients with CRSNP.
方法：采用乙酰甲胆碱支气管激发试验（MBPT）评价2004年1月～2006年6月间在首尔国立大学医院最近确诊患有CRSNP的122例连续病例的BHP。分析以下参数：症状、特应反应状态、现在吸烟、根据鼻窦CT的Lund-Mackay 评分系统确定的 CRSNP的疾病严重程度及血清和鼻组织中的嗜酸性粒细胞计数，并在BHP组和非BHP组间比较这些参数。
结果：35%的患者有BHR，且BHR在目前患有喷嚏的患者中更常见（P = 0.007）。此外，血清和鼻组织中的嗜酸性粒细胞计数的平均值BHR组高于非BHR组（血清P = 0.001，鼻组织P = 0.045），且血清嗜酸性粒细胞计数与鼻组织嗜酸性粒细胞计数相关（r = 0.334, P = 0.013）。两组比较，Lund-Mackay 评分系统确定的疾病严重程度无差异（P > 0.05）。CRSNP患者中预测BHR的最佳的血清嗜酸性粒细胞计数界值为300个细胞/微升（敏感度为70%，特异度为70%）。
结论：总的说来，这些结果表明中重度喷嚏和血清嗜酸性粒细胞计数≥300个细胞/微升可能是CRSNP患者中BHR的预测因子。
（张永明 审校）
Han DH, et al. Allergy. 2009 Jan;64(1):118-22. Epub 2008 Dec 17. Links
Han DH, et al. Allergy. 2009 Jan;64(1):118-22. Epub 2008 Dec 17. Links
Predictors of bronchial hyperresponsiveness in chronic rhino sinusitis with nasal polyp.
BACKGROUND: Chronic rhinosinusitis with nasal polyposis (CRSNP) and asthma are inflammatory lesions of the respiratory epithelium. This study was conducted to evaluate predictive factors of bronchial hyperresponsiveness (BHR) in patients with CRSNP.
METHODS: BHR was evaluated using a methacholine bronchoprovocation test (MBPT) in 122 consecutive patients newly diagnosed with CRSNP at Seoul National University Hospital from January 2004 to June 2006. The following parameters were analyzed and compared between the BHR and non-BHR groups: symptoms, atopic status, current smoking, disease severity of CRSNP based on the Lund-Mackay scoring system of sinus CT, and counts of eosinophils in the serum and nasal tissues.
RESULTS: Thirty-five percent of the patients were found to have BHR, and BHR was found to occur more frequently in patients that were currently suffering from sneezing (P = 0.007). In addition, the mean eosinophil counts of the serum and nasal tissues were higher in the BHR group than in the non-BHR group (P = 0.001 for the serum, P = 0.045 for the nasal tissues), and the eosinophil counts of the serum correlated to those of the nasal tissues (r = 0.334, P = 0.013). The disease severity, as determined by the Lund-Mackay scoring system, was not different between the two groups (P > 0.05). The best cutoff serum eosinophil count for predicting BHR in CRSNP patients was determined to be 300 cells/microl (sensitivity 70%, specificity 70%).
CONCLUSION: Taken together, these results indicate that moderate to severe sneezing and a serum eosinophil count > or = 300 cells/microl may be predictive factors for BHR in patients with CRSNP.
上一篇：
定量CT检测气流闭陷的哮喘表型的危险因素—一项多因素分析
下一篇：
慢性阻塞性肺疾病和哮喘患者的C反应蛋白水平
