过敏性鼻炎血清嗜酸性粒细胞蛋白能够预测哮喘风险
2009/03/20
背景：过敏性鼻炎是一种常见疾病，其中某些患者的病情可能恶化或发展为哮喘。因此，认识这些患者的特点，从而提供可能的预防措施十分重要。本研究评价了可能表明过敏性呼吸道疾病恶化的嗜酸性粒细胞的各项参数。
方法：本研究的研究对象包括患季节性过敏性鼻炎并在6年前参加过某项研究的所有患者，6年前的研究检测了患者的血嗜酸性粒细胞、血清嗜酸性粒细胞阳离子蛋白（ECP）和嗜酸性粒细胞过氧化物酶（EPO）及鼻灌洗液中的ECP和EPO水平。本研究中检查患者在上一季节期间出现的鼻炎症状、上一季节后的鼻炎情况、哮喘样症状和哮喘确诊情况，并对常见空气过敏原进行了皮肤点刺试验。然后检测了6年前研究所得的嗜酸性粒细胞的各项参数对过敏新发病例、鼻炎加重和发生哮喘的预测能力。
结果：本研究纳入44名患者。4名患有季节性鼻炎症状的患者病情恶化，10名患者出现常年性鼻炎症状，14名患者有哮喘样症状，7名患者确诊患有哮喘。13名患者出现其他过敏反应。与未出现哮喘样症状的患者相比，有哮喘样症状的患者其血清ECP（16.7 mg/l vs 8.2 mg/l; P</= 0.01）和血清EPO（17.9 mg/l vs 8.8 mg/l; P </= 0.05）明显升高。确诊患有哮喘的患者其结果相似。血嗜酸性粒细胞和鼻灌洗参数与出现哮喘和哮喘样症状无关。未见嗜酸性粒细胞参数与鼻炎加重或其他过敏反应有关。
结论：患有季节性鼻炎的患者中血清ECP和EPO可很好预测哮喘的发生。
（林江涛 审校）
Nielsen LP, et al. Allergy. 2008 Dec 24. [Epub ahead of print]
Nielsen LP, et al. Allergy. 2008 Dec 24. [Epub ahead of print]
Serum eosinophil granule proteins predict asthma risk in allergic rhinitis.
Background: Allergic rhinitis is a common disease, in which some patients will deteriorate or develop asthma. It is important to characterize these patients, thereby offering the possibility for prevention. This study evaluated eosinophil parameters as potential indicators of deteriorating allergic airway disease.
Methods: The subjects of the study included all patients who suffered seasonal allergic rhinitis and had participated in a study 6 years earlier, in which blood eosinophils, serum eosinophil cationic protein (ECP) serum eosinophil peroxidase (EPO), nasal lavage ECP and nasal lavage EPO levels were measured. Patients in the present study were interviewed on occurrence of rhinitis symptoms during the last season, rhinitis outside season, asthma-like symptoms and asthma diagnosis, and were skin-prick tested for common aeroallergens. Eosinophil parameters from the study 6 years earlier were then tested for the ability to predict occurrence of new allergies, worsening of rhinitis and occurrence of asthma.
Results: Forty-four patients participated in the study. In four patients seasonal rhinitis symptoms had deteriorated, 10 had experienced perennial rhinitis symptoms, 14 reported asthma-like symptoms and seven had been diagnosed with asthma. Thirteen had developed additional sensitization. Patients developing asthma-like symptoms compared with patients with no such symptoms had significantly higher serum ECP (16.7 mug/l vs 8.2 mug/l; PConclusion: Serum ECP and EPO in patients with seasonal rhinitis demonstrated a high predictive ability for later development of asthma.
方法：本研究的研究对象包括患季节性过敏性鼻炎并在6年前参加过某项研究的所有患者，6年前的研究检测了患者的血嗜酸性粒细胞、血清嗜酸性粒细胞阳离子蛋白（ECP）和嗜酸性粒细胞过氧化物酶（EPO）及鼻灌洗液中的ECP和EPO水平。本研究中检查患者在上一季节期间出现的鼻炎症状、上一季节后的鼻炎情况、哮喘样症状和哮喘确诊情况，并对常见空气过敏原进行了皮肤点刺试验。然后检测了6年前研究所得的嗜酸性粒细胞的各项参数对过敏新发病例、鼻炎加重和发生哮喘的预测能力。
结果：本研究纳入44名患者。4名患有季节性鼻炎症状的患者病情恶化，10名患者出现常年性鼻炎症状，14名患者有哮喘样症状，7名患者确诊患有哮喘。13名患者出现其他过敏反应。与未出现哮喘样症状的患者相比，有哮喘样症状的患者其血清ECP（16.7 mg/l vs 8.2 mg/l; P</= 0.01）和血清EPO（17.9 mg/l vs 8.8 mg/l; P </= 0.05）明显升高。确诊患有哮喘的患者其结果相似。血嗜酸性粒细胞和鼻灌洗参数与出现哮喘和哮喘样症状无关。未见嗜酸性粒细胞参数与鼻炎加重或其他过敏反应有关。
结论：患有季节性鼻炎的患者中血清ECP和EPO可很好预测哮喘的发生。
（林江涛 审校）
Nielsen LP, et al. Allergy. 2008 Dec 24. [Epub ahead of print]
Nielsen LP, et al. Allergy. 2008 Dec 24. [Epub ahead of print]
Serum eosinophil granule proteins predict asthma risk in allergic rhinitis.
Background: Allergic rhinitis is a common disease, in which some patients will deteriorate or develop asthma. It is important to characterize these patients, thereby offering the possibility for prevention. This study evaluated eosinophil parameters as potential indicators of deteriorating allergic airway disease.
Methods: The subjects of the study included all patients who suffered seasonal allergic rhinitis and had participated in a study 6 years earlier, in which blood eosinophils, serum eosinophil cationic protein (ECP) serum eosinophil peroxidase (EPO), nasal lavage ECP and nasal lavage EPO levels were measured. Patients in the present study were interviewed on occurrence of rhinitis symptoms during the last season, rhinitis outside season, asthma-like symptoms and asthma diagnosis, and were skin-prick tested for common aeroallergens. Eosinophil parameters from the study 6 years earlier were then tested for the ability to predict occurrence of new allergies, worsening of rhinitis and occurrence of asthma.
Results: Forty-four patients participated in the study. In four patients seasonal rhinitis symptoms had deteriorated, 10 had experienced perennial rhinitis symptoms, 14 reported asthma-like symptoms and seven had been diagnosed with asthma. Thirteen had developed additional sensitization. Patients developing asthma-like symptoms compared with patients with no such symptoms had significantly higher serum ECP (16.7 mug/l vs 8.2 mug/l; PConclusion: Serum ECP and EPO in patients with seasonal rhinitis demonstrated a high predictive ability for later development of asthma.
