女性患者血清脂连素浓度与哮喘相关
2009/03/10
近年研究发现，肥胖可能是支气管哮喘的危险因素之一，尤其在女性患者，肥胖与哮喘的相关性更为显著。而肥胖与脂肪细胞因子脂连素的异常表达有关，肥胖患者血清脂连素浓度降低。最近的一项研究探讨了血清脂连素浓度与哮喘的相关性，试图进一步解释肥胖与哮喘的相关性。他们的研究共纳入2890个患者，以当前哮喘诊断为因变量进行多变量逻辑回归分析。
结果发现，正在患哮喘的女性患者，而不是男性患者，血清脂连素浓度较从未患哮喘的患者显著降低；当前诊断哮喘的病例数仅与女性肥胖患者数相关；在具有高水平血清脂连素的绝经前女性患者中，当前哮喘患病率降低最显著。他们的研究认为，高水平血清脂连素能够降低绝经前女性患哮喘的风险，但这一结果并不说明哮喘与肥胖相关。
（毛辉 四川大学华西医院呼吸科 610041 摘译 ）
（Thorax. 2008 Oct;63(10):877-882.）
Sood A, Cui X, Qualls C, Beckett WS, Gross MD, Steffes MW, Smith LJ, Jacobs DR Jr.
Association between asthma and serum adiponectin concentration in women.
Thorax. 2008 Oct;63(10):877-82. Epub 2008 Apr 4.
Background: The association of murine asthma with adiposity may be mediated by adiponectin, an anti-inflammatory adipokine with reduced serum concentrations in obese subjects. A study was undertaken to examine whether the serum adiponectin concentration is associated with human asthma and whether it explains the association between adiposity and asthma, particularly in women and in premenopausal women.
Methods: A cross-sectional analysis was performed of 2890 eligible subjects at year 15 of the Coronary Artery Risk Development in Young Adults (CARDIA) cohort and its YALTA ancillary study who had either current asthma or never asthma at that evaluation. Obesity was defined as body mass index (BMI) >30 kg/m2. Multivariable logistic regression analysis was performed with current asthma status as the dependent variable.
Results: Women, but not men, with current asthma had a lower mean unadjusted serum adiponectin concentration than those with never asthma (p,0.001; p for sex interaction ,0.001). Similarly, current asthma was related to obesity only in women (OR 3.31, 95% CI 2.00 to 5.46, p for sex interaction=0.004); this association was little affected by adjusting for serum adiponectin. The prevalence of current asthma in premenopausal women was reduced in the highest compared with the lowest tertile of serum adiponectin concentration (OR 0.46, 95% CI 0.26 to 0.84, p=0.03), after adjusting for BMI. However, the interaction between serum adiponectin concentration and BMI category on current asthma status was not significant in premenopausal women or women overall.
Conclusions: A high serum adiponectin concentration may protect against current asthma in premenopausal women but does not explain the association between asthma and adiposity.
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根据哮喘指南联合应用呼出气NO测定管理内陆城市青少年和年轻成人哮喘患者：一项随机对照研究
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