哮喘联盟

    文章指出：呼吸系统感染可以增加维生素D介导的先天免疫，尤其是通过增加hCAP-18（the human cathelicidin antimicrobial peptide）的表达，这是宿主对抗呼吸道病原非常重要的防御反应。
    研究显示，维生素D缺乏会增加呼吸道感染的风险。这种增加的风险会诱发儿童和成年人的喘息，以及哮喘的急性发作。尽管还没有证明，易感宿主的特殊呼吸道感染会增加哮喘事件。维生素D可以调节T细胞的功能和IL-10的产生，可以增加激素抵抗型哮喘对激素的治疗反应。将来应在实验室、流行病学和随机研究中，更好的了解在呼吸道感染和哮喘方面维生素D的作用。

（苏楠 卫生部中日友好医院呼吸内科 100029 摘译）
（Curr Allergy Asthma Rep. 2009 Jan;9(1):81-87）

Curr Allergy Asthma Rep. 2009 Jan;9(1):81-87.

Vitamin D, Respiratory Infections, and Asthma.

Ginde AA, Mansbach JM, Camargo Jr CA.

EMNet Coordinating Center, Massachusetts General Hospital, 326 Cambridge Street, Suite 410, Boston, MA 02114, USA. ccamargo@partners.org.

Over the past decade, interest has grown in the role of vitamin D in many nonskeletal medical conditions, including respiratory infection. Emerging evidence indicates that vitamin D-mediated innate immunity, particularly through enhanced expression of the human cathelicidin antimicrobial peptide (hCAP-18), is important in host defenses against respiratory tract pathogens. Observational studies suggest that vitamin D deficiency increases risk of respiratory infections. This increased risk may contribute to incident wheezing illness in children and adults and cause asthma exacerbations. Although unproven, the increased risk of specific respiratory infections in susceptible hosts may contribute to some cases of incident asthma. Vitamin D also modulates regulatory T-cell function and interleukin-10 production, which may increase the therapeutic response to glucocorticoids in steroid-resistant asthma. Future laboratory, epidemiologic, and randomized interventional studies are needed to better understand vitamin D’s effects on respiratory infection and asthma.