哮喘母亲怀孕期间使用吸入糖皮质激素是安全的
2007/11/02
哮喘患者血管增生与哮喘功能异常有关。这个研究探讨了吸入糖皮质激素是否通过血管内皮生长因子及其受体调节血管的发生。
结果发现，吸入糖皮质激素3个月后，支气管粘膜活检发现血管内皮生长因子表达下降，但灌洗液中血管内皮生长因子的水平没有明显变化。这个研究表明吸入糖皮质激素下向调节哮喘患者气道血管源性重塑，通过降低气道局部血管内皮生长因子的水平。
(高金明 北京协和医院呼吸科 100730 摘译)
(Thorax 2007; 62:314-319)
Effects of inhaled fluticasone on angiogenesis and vascular endothelial growth factor in asthma Thorax 2007; 62:314-319.
This placebo-controlled intervention study was undertaken to explore angiogenic modulation by ICS and its likely regulation via vascular endothelial growth factor (VEGF), its receptors and the angiopoietins. The findings included that vessel, VEGF and sprout staining were decreased after 3 months of ICS treatment. VEGF levels remained unchanged. VEGF receptors and Ang1 staining were not reduced after treatment. The findings of this study support an effect of ICS in downregulating angiogenic remodelling in the airways in asthma, associated with decreasing VEGF activity within the airway wall. The environment of the airways after treatment with ICS, with changes in the balance between VEGF, its receptors, Ang1 and sprouts, appears to be less angiogenic than in untreated asthma.
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哮喘患者血管形成素I和Ⅱ在气道微血管渗漏中的作用
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