PAS研究：评价基于网络的多项个性化戒烟项目和护理人员个性化戒烟咨询在戒烟过程中的有效性的随机对照试验
2010/07/07
背景：PAS（戒烟的个性化建议）包括两项最为有效的戒烟干预措施：多项电脑个性化戒烟项目和护理人员个性化戒烟咨询。
方法/设计：自2009年5月，护理人员募集吸烟患者。6个月内，每位护理人员选取15名有戒烟意向的成人吸烟者，这些吸烟者能使用网络。吸烟者注册并登录PAS网站，随机分为下列3组：多项个性化戒烟和个性化咨询组（MTC）、多项个性化戒烟组（MT）和常规护理组（UC）。在基线状态、戒烟后2天、随访6周、6个月和12个月后，采用问卷对患者进行调查。MT组吸烟者在前4个检测点，采用个性化的、反复回馈信件调查。对主诉戒烟有效的吸烟者在随访12个月后采用生化方法检测戒烟。采用logistic多水平线性回归分析，比较三组吸烟者中有戒烟欲望的吸烟者比例、点戒断率和持续戒断率。多水平线性回归分析用于比较三组参与者吸烟相关信念。
讨论：本文对PAS的过程、设计及其在戒烟中的有效性进行了详细描述。有助于深入了解PAS有效工作的机制。我们结果有助于了解成人吸烟者戒烟干预措施的有效性。
（陈欣 审校）
Smit ES, et al. Contemp Clin Trials. 2010 Mar 6. [Epub ahead of print]
The PAS study: A randomized controlled trial evaluating the effectiveness of a web-based multiple tailored smoking cessation programme and tailored counselling by practice nurses.
Smit ES, de Vries H, Hoving C.
Department of Health Promotion, School for Public Health and Primary Care (Caphri), Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.
BACKGROUND: PAS (Personal Advice in Stopping smoking) combines two of the most effective smoking cessation interventions: multiple computer tailoring and tailored counselling by a practice nurse in the general practice.
METHODS/DESIGN: Since May 2009, practice nurses are recruiting smoking patients. Each practice nurse is asked to recruit 15 adult smokers who are willing to quit within 6months and have access to the Internet. Smokers can sign up for PAS through the PAS website and are then randomized into one of three groups receiving multiple tailoring and counselling (MTC), multiple tailoring (MT) or usual care (UC), respectively. All groups receive questionnaires at baseline, 2days after a set quit date and at 6weeks, 6months and 12months follow-up. The MT group receives tailored, iterative feedback letters at the first four measurements points. At 12months follow-up biochemical validation will take place amongst respondents reporting to have quit. The three groups will be compared with regard to quit attempt rate, point prevalence abstinence and continued abstinence by means of logistic multilevel regression analyses. Linear multilevel regression analyses will be used to compare the three groups regarding smoking related beliefs.
DISCUSSION: The present paper provides an extensive description of the development of PAS and of the design of the study towards its effectiveness. This might provide insight into PAS’ potentially effective working mechanisms. The results concerning effectiveness may contribute to knowledge about the effectiveness of smoking cessation interventions aimed at smoking adults.
TRIAL REGISTRATION: Dutch Trial Register NTR1351
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生活质量和抑郁情绪对现患疾病吸烟者戒烟的影响
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柏林医学生的吸烟习惯、对吸烟的了解以及对戒烟咨询的态度
