在暴露于过敏原的小鼠中，环境中烟草烟雾暴露不会降低糖皮质激素减轻炎症、重构和气道高反应的作用
2009/08/11
糖皮质激素能降低气道炎症，改善肺功能，但与非吸烟的哮喘患者相比，糖皮质激素的上述作用在吸烟的哮喘患者中被明显减弱。因为不管是在有较高烟草烟雾暴露水平的主动吸烟者中，还是在仅有低水平被动环境烟草烟雾（ETS）暴露的不吸烟者中，烟草烟雾都可以使哮喘症状加重，哮喘恶化频率增加，所以我们在长期暴露于ETS和OVA过敏原的小鼠模型中来观察糖皮质激素是否能降低气道炎症水平、气道重构水平或气道高反应性。
单纯长期ETS暴露不能导致嗜酸性粒细胞性气道炎症水平、气道重构水平或气道高反应性的升高。小鼠长期OVA过敏原暴露，能导致支气管周围纤维化、支气管平滑肌层厚度、粘液分泌量以及气道高反应性增加，而且若伴随有长期ETS暴露则能增加上述作用。长期暴露于ETS和OVA的小鼠在给予糖皮质激素后，能显著降低嗜酸性粒细胞性气道炎症、粘液分泌量、支气管平滑肌厚度、气道高反应性以及支气管周围的TGF-β1+细胞。
本研究结果显示，在长期暴露于ETS和过敏原的小鼠中，糖皮质激素能显著降低嗜酸性粒细胞性炎症、粘液分泌量、气道重构和气道高反应。
（陈欣 审校）
Song DJ, et al. Am J Physiol Lung Cell Mol Physiol. 2009 Jun 12. [Epub ahead of print]
Environmental Tobacco Smoke Exposure Does Not Prevent Corticosteroids Reducing Inflammation, Remodeling, and Airway Hyperreactivity in Mice Exposed to Allergen.
Song DJ, Min MG, Miller M, Cho JY, Broide DH.
University of California San Diego.
The ability of corticosteroids to reduce airway inflammation and improve lung function is significantly reduced in asthmatics who are tobacco smokers compared to asthmatics who are non-smokers. As not only high levels of tobacco smoke exposure in active smokers, but also significantly lower levels of tobacco smoke exposure from passive environmental tobacco smoke (ETS) exposure in non-smokers can increase both asthma symptoms and the frequency of asthma exacerbations, we utilized a mouse model to determine whether corticosteroids can reduce levels of airway inflammation, airway remodeling, and airway hyperreactivity in mice exposed to the combination of chronic ETS and OVA allergen. Chronic ETS exposure alone did not induce increases in eosinophilic airway inflammation, airway remodeling, or airway hyperreactivity. Mice exposed to chronic OVA allergen had significantly increased levels of peribronchial fibrosis, increased thickening of the smooth muscle layer, increased mucus, and increased airway hyperreactivity which was significantly enhanced by co-exposure to the combination of chronic ETS and chronic OVA allergen. Administration of corticosteroids to mice exposed to chronic ETS and OVA allergen significantly reduced levels of eosinophilic airway inflammation, mucus production, peribronchial smooth muscle thickness, airway hyperreactivity, and the number of peribronchial TGF-beta1+ cells. Overall, this study demonstrates that corticosteroids can significantly reduce levels of eosinophilic inflammation, mucus expression, airway remodeling, and airway hyperreactivity in chronic ETS exposed mice challenged with allergen. Key words: allergy, inflammation, eosinophils.
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