吸烟与人体天然免疫
2009/07/30
目的：回顾吸烟的免疫抑制效果以及影响烟民天然免疫功能的相关机制。
方法：综述回顾吸烟的免疫抑制作用，分析吸烟引起免疫抑制的机制，包括吸烟如何引起呼吸道上皮细胞、肺表面活性物质和肺泡巨噬细胞、中性粒细胞、淋巴细胞和自然杀伤细胞等免疫细胞的结构和功能改变来影响宿主天然免疫功能。
结论：不仅在癌症和冠心病的预防中强调戒烟，而且在反复感染和免疫抑制状态的患者中戒烟同样起到举足轻重的作用。
方法：综述回顾吸烟的免疫抑制作用，分析吸烟引起免疫抑制的机制，包括吸烟如何引起呼吸道上皮细胞、肺表面活性物质和肺泡巨噬细胞、中性粒细胞、淋巴细胞和自然杀伤细胞等免疫细胞的结构和功能改变来影响宿主天然免疫功能。
结论：不仅在癌症和冠心病的预防中强调戒烟，而且在反复感染和免疫抑制状态的患者中戒烟同样起到举足轻重的作用。
（张永明编译刘国梁审校）
Inflamm Res. 2008 Nov;57(11):497-503
Cigarette smoking and innate immunity.
Mehta H, Nazzal K, Sadikot RT.
Department of Veterans Affairs, University of Illinois and Cook County Hospital, Chicago, IL, USA.
Cigarette smoking is a worldwide epidemic and the most prevalent cause of many diseases leading to increased morbidity and mortality globally. The impact of smoking on pathogenesis of cancer is being extensively studied however cigarette smoke as an immunosuppressant is less well recognized. Here we review the immunosuppressive effects of cigarette smoke and the mechanisms by which smoking affects host innate immunity including structural and functional changes in the respiratory ciliary epithelium, lung surfactant protein, and immune cells such as alveolar macrophages, neutrophils, lymphocytes and natural killer (NK) cells. Thus smoking cessation should be emphasized not only for prevention of cancer and coronary artery disease but also for patients with recurrent infections and immunosuppressive states.
PMID: 19109742 [PubMed - in process]
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