评估特定PM2.5结合的金属元素对哮喘急诊就诊的影响：一项台湾病例交叉研究
2024/06/26
摘要
背景：本研究采用病例交叉研究设计，旨在评估导致哮喘急诊就诊的特定 PM2.5 结合的金属元素。
方法：本研究分析了 2017 年至 2020 年期间作为病例组的 11,410 次哮喘急诊就诊数据，以及作为对照组的 22,820 次病例日之前一周和两周的非哮喘发病日期数据。研究收集了台湾六个不同地区的PM2.5监测数据和35种与PM2.5结合的金属元素。条件logistic回归模型用于评估哮喘与 PM2.5 结合的金属元素之间的关系。
结果：我们的调查显示，哮喘急诊就诊的风险与秋季0、1、2和3滞后期的PM2.5暴露有关，具有统计学意义。此外，PM2.5中的铪（Hf）、铊（Tl）、铷（Rb）和铝（Al）在1、2和3滞后期与哮喘急诊就诊率呈持续显著的正相关。在按地区、年龄和性别进行的分层分析中，PM2.5 结合的 Hf 显示出显著且一致的相关性。
结论：本研究提供了 PM2.5 结合的金属元素对哮喘恶化有影响的证据，尤其是对 Hf 的影响。它强调了了解这些金属元素的来源和减少排放以降低区域健康风险的重要性。
Assessing the impact of specific PM2.5-Bound metallic elements on asthma emergency department visits: A case-crossover study in Taiwan
Kono M, Su TY, Chang YY, Chou CC, Lee CT, Chen PC, Wu WT.
Abstract
Background:This study aims to assess the specific PM2.5-bound metallic elements that contribute to asthma emergency department visits by using a case-crossover study design.
Methods:This study analyzed data from 11,410 asthma emergency department visits as case group and 22,820 non-asthma onset dates occurring one week and two weeks preceding the case day as controls from 2017 to 2020. PM2.5 monitoring data and 35 PM.2.5-bound metallic elements from six different regions in Taiwan were collected. Conditional logistic regression models were used to assess the relationship between asthma and PM2.5-bound metallic elements.
Results:Our investigation revealed a statistically significant risk of asthma emergency department visits associated with PM2.5 exposure at lag 0, 1, 2, and 3 during autumn. Additionally, PM2.5-bound hafnium (Hf), thallium (Tl), rubidium (Rb), and aluminum (Al) exhibited a consistently significant positive correlation with asthma emergency department visits at lags 1, 2, and 3. In stratified analyses by area, age, and sex, PM2.5-bound Hf showed a significant and consistent correlation.
Conclusion:This study provides evidence of PM2.5-bound metallic elements effects in asthma exacerbations, particularly for Hf. It emphasizes the importance of understanding the origins of these metallic elements and pursuing emission reductions to mitigate regional health risks.
背景：本研究采用病例交叉研究设计，旨在评估导致哮喘急诊就诊的特定 PM2.5 结合的金属元素。
方法：本研究分析了 2017 年至 2020 年期间作为病例组的 11,410 次哮喘急诊就诊数据，以及作为对照组的 22,820 次病例日之前一周和两周的非哮喘发病日期数据。研究收集了台湾六个不同地区的PM2.5监测数据和35种与PM2.5结合的金属元素。条件logistic回归模型用于评估哮喘与 PM2.5 结合的金属元素之间的关系。
结果：我们的调查显示，哮喘急诊就诊的风险与秋季0、1、2和3滞后期的PM2.5暴露有关，具有统计学意义。此外，PM2.5中的铪（Hf）、铊（Tl）、铷（Rb）和铝（Al）在1、2和3滞后期与哮喘急诊就诊率呈持续显著的正相关。在按地区、年龄和性别进行的分层分析中，PM2.5 结合的 Hf 显示出显著且一致的相关性。
结论：本研究提供了 PM2.5 结合的金属元素对哮喘恶化有影响的证据，尤其是对 Hf 的影响。它强调了了解这些金属元素的来源和减少排放以降低区域健康风险的重要性。
(中日友好医院呼吸与危重症医学科 沈焜路 摘译 林江涛 审校)
(Environ Res. 2024 Aug 1; DOI: 10.1016/j.envres.2024.119130)
(Environ Res. 2024 Aug 1; DOI: 10.1016/j.envres.2024.119130)
Assessing the impact of specific PM2.5-Bound metallic elements on asthma emergency department visits: A case-crossover study in Taiwan
Kono M, Su TY, Chang YY, Chou CC, Lee CT, Chen PC, Wu WT.
Abstract
Background:This study aims to assess the specific PM2.5-bound metallic elements that contribute to asthma emergency department visits by using a case-crossover study design.
Methods:This study analyzed data from 11,410 asthma emergency department visits as case group and 22,820 non-asthma onset dates occurring one week and two weeks preceding the case day as controls from 2017 to 2020. PM2.5 monitoring data and 35 PM.2.5-bound metallic elements from six different regions in Taiwan were collected. Conditional logistic regression models were used to assess the relationship between asthma and PM2.5-bound metallic elements.
Results:Our investigation revealed a statistically significant risk of asthma emergency department visits associated with PM2.5 exposure at lag 0, 1, 2, and 3 during autumn. Additionally, PM2.5-bound hafnium (Hf), thallium (Tl), rubidium (Rb), and aluminum (Al) exhibited a consistently significant positive correlation with asthma emergency department visits at lags 1, 2, and 3. In stratified analyses by area, age, and sex, PM2.5-bound Hf showed a significant and consistent correlation.
Conclusion:This study provides evidence of PM2.5-bound metallic elements effects in asthma exacerbations, particularly for Hf. It emphasizes the importance of understanding the origins of these metallic elements and pursuing emission reductions to mitigate regional health risks.
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